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Bmper BMP-binding endothelial regulator [ Rattus norvegicus (Norway rat) ]

Gene ID: 300455, updated on 2-Nov-2024

Summary

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Official Symbol
Bmperprovided by RGD
Official Full Name
BMP-binding endothelial regulatorprovided by RGD
Primary source
RGD:1563373
See related
EnsemblRapid:ENSRNOG00000015357 AllianceGenome:RGD:1563373
Gene type
protein coding
RefSeq status
INFERRED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1563373
Summary
Predicted to be involved in several processes, including blood vessel endothelial cell proliferation involved in sprouting angiogenesis; cell surface receptor protein serine/threonine kinase signaling pathway; and positive regulation of intracellular signal transduction. Predicted to act upstream of or within inner ear development and negative regulation of BMP signaling pathway. Predicted to be located in extracellular region. Predicted to be active in extracellular matrix and extracellular space. Human ortholog(s) of this gene implicated in opiate dependence. Orthologous to human BMPER (BMP binding endothelial regulator). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 45.1), Muscle (RPKM 20.7) and 7 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Bmper in Genome Data Viewer
Location:
8q13
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (30008049..30253201)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (21732225..21977261)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (24369916..24615484)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480001 Neighboring gene uncharacterized LOC103693030 Neighboring gene uncharacterized LOC134480002 Neighboring gene uncharacterized LOC134479969 Neighboring gene uncharacterized LOC102556684

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. BMPER is an endothelial cell regulator and controls bone morphogenetic protein-4-dependent angiogenesis. Heinke J, et al. Circ Res, 2008 Oct 10. PMID 18787191
  2. BMPER, a novel endothelial cell precursor-derived protein, antagonizes bone morphogenetic protein signaling and endothelial cell differentiation. Moser M, et al. Mol Cell Biol, 2003 Aug. PMID 12897139, Free PMC Article
  3. Bone morphogenetic protein 4 regulates microRNAs miR-494 and miR-126-5p in control of endothelial cell function in angiogenesis. Esser JS, et al. Thromb Haemost, 2017 Apr 3. PMID 28124060
  4. Substance dependence low-density whole genome association study in two distinct American populations. Yu Y, et al. Hum Genet, 2008 Jun. PMID 18438686, Free PMC Article
  5. Spatial gene expression in the T-stage mouse metanephros. Caruana G, et al. Gene Expr Patterns, 2006 Oct. PMID 16545622

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in SMAD protein signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in blood vessel development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in blood vessel endothelial cell proliferation involved in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in endothelial cell activation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within inner ear development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of SMAD protein signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of endothelial cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of protein localization ISO
Inferred from Sequence Orthology
more info
  
involved_in ureteric bud development ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
BMP-binding endothelial regulator protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135799.1 → NP_001129271.1  BMP-binding endothelial regulator protein precursor

    See identical proteins and their annotated locations for NP_001129271.1

    Status: INFERRED

    Source sequence(s)
    CH474007
    UniProtKB/TrEMBL
    A0A8I6GMI8, A6JYA2, F1M661
    Related
    ENSRNOP00000038791.5, ENSRNOT00000033460.7
    Conserved Domains (5) summary
    pfam00093
    Location:166 → 224
    VWC; von Willebrand factor type C domain
    pfam00094
    Location:364 → 508
    VWD; von Willebrand factor type D domain
    pfam01826
    Location:629 → 682
    TIL; Trypsin Inhibitor like cysteine rich domain
    pfam08742
    Location:556 → 624
    C8; C8 domain
    cl17735
    Location:301 → 357
    VWC; von Willebrand factor type C domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    30008049..30253201
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006242715.5 → XP_006242777.1  BMP-binding endothelial regulator protein isoform X1

    Conserved Domains (5) summary
    pfam00093
    Location:87 → 145
    VWC; von Willebrand factor type C domain
    pfam00094
    Location:285 → 429
    VWD; von Willebrand factor type D domain
    pfam01826
    Location:550 → 603
    TIL; Trypsin Inhibitor like cysteine rich domain
    pfam08742
    Location:477 → 545
    C8; C8 domain
    cl17735
    Location:222 → 278
    VWC; von Willebrand factor type C domain

  2. XM_039081015.2 → XP_038936943.1  BMP-binding endothelial regulator protein isoform X2

    Conserved Domains (5) summary
    pfam00093
    Location:61 → 119
    VWC; von Willebrand factor type C domain
    cl17735
    Location:196 → 252
    VWC; von Willebrand factor type C domain
    pfam00094
    Location:259 → 403
    VWD; von Willebrand factor type D domain
    pfam08742
    Location:455 → 519
    C8; C8 domain
    cd19941
    Location:524 → 577
    TIL; trypsin inhibitor-like cysteine rich domain

  3. XM_039081016.2 → XP_038936944.1  BMP-binding endothelial regulator protein isoform X3

    Conserved Domains (4) summary
    cl17735
    Location:83 → 139
    VWC; von Willebrand factor type C domain
    pfam00094
    Location:146 → 290
    VWD; von Willebrand factor type D domain
    pfam08742
    Location:342 → 406
    C8; C8 domain
    cd19941
    Location:411 → 464
    TIL; trypsin inhibitor-like cysteine rich domain

RNA

  1. XR_010053940.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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