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Reg3d regenerating islet-derived 3 delta [ Mus musculus (house mouse) ]

Gene ID: 30053, updated on 2-Nov-2024

Summary

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Official Symbol
Reg3dprovided by MGI
Official Full Name
regenerating islet-derived 3 deltaprovided by MGI
Primary source
MGI:MGI:1353426
See related
Ensembl:ENSMUSG00000068341 AllianceGenome:MGI:1353426
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
INGAP; Ingaprp
Summary
Predicted to enable oligosaccharide binding activity; peptidoglycan binding activity; and signaling receptor activity. Predicted to be involved in antimicrobial humoral immune response mediated by antimicrobial peptide; positive regulation of cell population proliferation; and response to peptide hormone. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in small intestine adult (RPKM 13.5), spleen adult (RPKM 3.6) and 2 other tissues See more
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Genomic context

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See Reg3d in Genome Data Viewer
Location:
6 C3; 6 34.76 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (78352857..78355848, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (78375874..78378865, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted pseudogene 5576 Neighboring gene STARR-seq mESC enhancer starr_16386 Neighboring gene STARR-seq mESC enhancer starr_16388 Neighboring gene regenerating islet-derived 3 beta Neighboring gene regenerating islet-derived 3 alpha Neighboring gene regenerating islet-derived 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Molecular cloning and tissue-specific expression of a new member of the regenerating protein family, islet neogenesis-associated protein-related protein. Sasahara K, et al. Biochim Biophys Acta, 2000 Jan 3. PMID 10564727
  2. Targeted expression of islet neogenesis associated protein to beta cells enhances glucose tolerance and confers resistance to streptozotocin-induced hyperglycemia. Chang TJ, et al. Mol Cell Endocrinol, 2011 Mar 30. PMID 21187123
  3. Pancreatic islet immunoreactivity to the Reg protein INGAP. Taylor-Fishwick DA, et al. J Histochem Cytochem, 2008 Feb. PMID 17998566, Free PMC Article
  4. The Reg family member INGAP is a marker of endocrine patterning in the embryonic pancreas. Hamblet NS, et al. Pancreas, 2008 Jan. PMID 18192873
  5. Identification of a novel Reg family gene, Reg IIIdelta, and mapping of all three types of Reg family gene in a 75 kilobase mouse genomic region. Abe M, et al. Gene, 2000 Apr 4. PMID 10767532

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2) 

General gene information

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Markers

Homology

Clone Names

  • MGC130575

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables oligosaccharide binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptidoglycan binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to peptide hormone IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
regenerating islet-derived 3 delta
Names
Reg III delta
islet neogenesis associated protein-related protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001161741.1 → NP_001155213.1  regenerating islet-derived 3 delta isoform 2 precursor

    See identical proteins and their annotated locations for NP_001155213.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AB035204, AI594831, BM055959
    Consensus CDS
    CCDS51815.1
    UniProtKB/TrEMBL
    G3UWG6
    Related
    ENSMUSP00000132220.2, ENSMUST00000167492.4
    Conserved Domains (1) summary
    cl02432
    Location:40 → 127
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain

  2. NM_013893.2 → NP_038921.2  regenerating islet-derived 3 delta isoform 1 precursor

    See identical proteins and their annotated locations for NP_038921.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AB035204, AI594831
    Consensus CDS
    CCDS20254.1
    UniProtKB/TrEMBL
    Q9JMH1, Q9QUS9
    Related
    ENSMUSP00000087096.2, ENSMUST00000089667.8
    Conserved Domains (1) summary
    cl02432
    Location:40 → 173
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    78352857..78355848 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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