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Nnmt nicotinamide N-methyltransferase [ Rattus norvegicus (Norway rat) ]

Gene ID: 300691, updated on 2-Nov-2024

Summary

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Official Symbol
Nnmtprovided by RGD
Official Full Name
nicotinamide N-methyltransferaseprovided by RGD
Primary source
RGD:1309606
See related
EnsemblRapid:ENSRNOG00000005930 AllianceGenome:RGD:1309606
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable nicotinamide N-methyltransferase activity. Involved in animal organ regeneration and response to xenobiotic stimulus. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in abdominal aortic aneurysm. Orthologous to human NNMT (nicotinamide N-methyltransferase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Liver (RPKM 45.2), Adrenal (RPKM 26.5) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Nnmt in Genome Data Viewer
Location:
8q23
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (57820156..57851301, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (48928663..48947734, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (52918437..52938172, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene similar to human chromosome 11 open reading frame 71 Neighboring gene RNA binding motif protein 7 Neighboring gene uncharacterized LOC120094143 Neighboring gene zinc finger and BTB domain containing 16 Neighboring gene uncharacterized LOC120094144 Neighboring gene uncharacterized LOC134480046

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Serum N1-Methylnicotinamide is Associated With Coronary Artery Disease in Chinese Patients. Liu M, et al. J Am Heart Assoc, 2017 Feb 7. PMID 28174167, Free PMC Article
  2. Methylation of nicotinamide in rat liver cytosol and its correlation with hepatocellular proliferation. Hoshino J, et al. Biochim Biophys Acta, 1982 Dec 17. PMID 6217846
  3. Nicotinamide methylation. Tissue distribution, developmental and neoplastic changes. Seifert R, et al. Biochim Biophys Acta, 1984 Sep 28. PMID 6236853
  4. Increase of nicotinamide methyltransferase and N1-methyl-nicotinamide oxidase activities in the livers of the rats administered alkylating agents. Ohkubo M, et al. Cancer Lett, 1983 Dec. PMID 6652621
  5. Gene expression analysis of renal carcinoma: adipose differentiation-related protein as a potential diagnostic and prognostic biomarker for clear-cell renal carcinoma. Yao M, et al. J Pathol, 2005 Feb. PMID 15682440

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Progression of pulmonary hypertension is associated with the activation of the NNMT-1-methylnicotinamide pathway.
    Title: Activation of the nicotinamide N-methyltransferase (NNMT)-1-methylnicotinamide (MNA) pathway in pulmonary hypertension.
  2. The downregulation of NNMT by PEITC is a novel finding that may represent an important mechanism for the cancer preventive effects of dietary PEITC.
    Title: Effect of orally administered phenethyl isothiocyanate on hepatic gene expression in rats.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables nicotinamide N-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nicotinamide N-methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables selenol Se-methyltransferase activity TAS
Traceable Author Statement
more info
  
Process Evidence Code Pubs
involved_in animal organ regeneration IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within methylation ISO
Inferred from Sequence Orthology
more info
  
involved_in nicotinamide metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of gluconeogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein deacetylation ISO
Inferred from Sequence Orthology
more info
  
involved_in response to xenobiotic stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
nicotinamide N-methyltransferase
NP_001100289.1
XP_038936990.1
XP_038936991.1
XP_038936993.1
XP_038936994.1
XP_038936995.1
XP_063121183.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106819.1 → NP_001100289.1  nicotinamide N-methyltransferase

    See identical proteins and their annotated locations for NP_001100289.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473975
    UniProtKB/TrEMBL
    A6J4A4, D4A605
    Conserved Domains (1) summary
    pfam01234
    Location:2 → 259
    NNMT_PNMT_TEMT; NNMT/PNMT/TEMT family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    57820156..57851301 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039081062.2 → XP_038936990.1  nicotinamide N-methyltransferase isoform X2

    Related
    ENSRNOP00000086644.2, ENSRNOT00000117251.2
    Conserved Domains (1) summary
    pfam01234
    Location:2 → 236
    NNMT_PNMT_TEMT; NNMT/PNMT/TEMT family

  2. XM_063265113.1 → XP_063121183.1  nicotinamide N-methyltransferase isoform X1

    UniProtKB/TrEMBL
    A6J4A4, D4A605

  3. XM_039081065.2 → XP_038936993.1  nicotinamide N-methyltransferase isoform X4

    Conserved Domains (1) summary
    cl17173
    Location:18 → 164
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  4. XM_039081066.2 → XP_038936994.1  nicotinamide N-methyltransferase isoform X4

    Conserved Domains (1) summary
    cl17173
    Location:18 → 164
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  5. XM_039081067.2 → XP_038936995.1  nicotinamide N-methyltransferase isoform X5

    Conserved Domains (1) summary
    cl17173
    Location:2 → 121
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  6. XM_039081063.2 → XP_038936991.1  nicotinamide N-methyltransferase isoform X3

    Conserved Domains (1) summary
    cl17173
    Location:2 → 136
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
Nucleotide Protein Strain
Heading Accession and Version

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