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Ttc12 tetratricopeptide repeat domain 12 [ Rattus norvegicus (Norway rat) ]

Gene ID: 300696, updated on 2-Nov-2024

Summary

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Official Symbol
Ttc12provided by RGD
Official Full Name
tetratricopeptide repeat domain 12provided by RGD
Primary source
RGD:1303264
See related
EnsemblRapid:ENSRNOG00000008595 AllianceGenome:RGD:1303264
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in axonemal dynein complex assembly and sperm axoneme assembly. Predicted to be active in centrosome and cytoplasm. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; alcohol dependence; drug dependence (multiple); nicotine dependence; and primary ciliary dyskinesia 45. Orthologous to human TTC12 (tetratricopeptide repeat domain 12). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Testes (RPKM 87.2), Kidney (RPKM 25.1) and 5 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ttc12 in Genome Data Viewer
Location:
8q23
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (58696381..58743857, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (49799916..49847940, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (53770685..53818873, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene dopamine receptor D2 Neighboring gene ankyrin repeat and kinase domain containing 1 Neighboring gene uncharacterized LOC102555969 Neighboring gene neural cell adhesion molecule 1 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. NCAM1-TTC12-ANKK1-DRD2 variants and smoking motives as intermediate phenotypes for nicotine dependence. Bidwell LC, et al. Psychopharmacology (Berl), 2015 Apr. PMID 25273375, Free PMC Article
  2. Hypermethylation of TTC12 gene in acute lymphoblastic leukemia. Wattanawaraporn R, et al. Leukemia, 2007 Nov. PMID 17657212
  3. A neurobiological pathway to smoking in adolescence: TTC12-ANKK1-DRD2 variants and reward response. Macare C, et al. Eur Neuropsychopharmacol, 2018 Oct. PMID 30104163, Free PMC Article
  4. ANKK1, TTC12, and NCAM1 polymorphisms and heroin dependence: importance of considering drug exposure. Nelson EC, et al. JAMA Psychiatry, 2013 Mar. PMID 23303482, Free PMC Article
  5. Association of haplotypic variants in DRD2, ANKK1, TTC12 and NCAM1 to alcohol dependence in independent case control and family samples. Yang BZ, et al. Hum Mol Genet, 2007 Dec 1. PMID 17761687

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC94947

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in axonemal dynein complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in axonemal dynein complex assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in sperm axoneme assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sperm axoneme assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
tetratricopeptide repeat protein 12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004246.2 → NP_001004246.1  tetratricopeptide repeat protein 12

    See identical proteins and their annotated locations for NP_001004246.1

    Status: PROVISIONAL

    Source sequence(s)
    BC079409
    UniProtKB/TrEMBL
    F7FHS8, Q68FR0
    Related
    ENSRNOP00000011454.6, ENSRNOT00000011454.7
    Conserved Domains (4) summary
    cd00020
    Location:612 → 704
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    sd00006
    Location:105 → 133
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:142 → 172
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:105 → 170
    TPR_11; TPR repeat

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    58696381..58743857 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006243004.5 → XP_006243066.1  tetratricopeptide repeat protein 12 isoform X1

    UniProtKB/TrEMBL
    A0A8I6GMH4, F7FHS8
    Related
    ENSRNOP00000097363.1, ENSRNOT00000102297.2
    Conserved Domains (4) summary
    cd00020
    Location:631 → 723
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    sd00006
    Location:124 → 152
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:161 → 191
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:124 → 189
    TPR_11; TPR repeat

  2. XM_006243005.5 → XP_006243067.1  tetratricopeptide repeat protein 12 isoform X2

    See identical proteins and their annotated locations for XP_006243067.1

    UniProtKB/TrEMBL
    F7FHS8, Q68FR0
    Conserved Domains (4) summary
    cd00020
    Location:612 → 704
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    sd00006
    Location:105 → 133
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:142 → 172
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:105 → 170
    TPR_11; TPR repeat
Nucleotide Protein Strain
Heading Accession and Version

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