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Tspan3 tetraspanin 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 300733, updated on 17-Aug-2024

Summary

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Official Symbol
Tspan3provided by RGD
Official Full Name
tetraspanin 3provided by RGD
Primary source
RGD:1359444
See related
EnsemblRapid:ENSRNOG00000016474 AllianceGenome:RGD:1359444
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Tm4sf8
Summary
Predicted to be integral component of plasma membrane. Orthologous to human TSPAN3 (tetraspanin 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 983.9), Heart (RPKM 609.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tspan3 in Genome Data Viewer
Location:
8q24
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (65442100..65465961, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (56546067..56569815, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (60806848..60830448, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene large ribosomal subunit protein eL21-like Neighboring gene proline-serine-threonine phosphatase-interacting protein 1 Neighboring gene ribosomal protein L17, pseudogene 2 Neighboring gene pseudopodium-enriched atypical kinase 1 Neighboring gene iron-sulfur cluster assembly 2, pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. OSP/claudin-11 forms a complex with a novel member of the tetraspanin super family and beta1 integrin and regulates proliferation and migration of oligodendrocytes. Tiwari-Woodruff SK, et al. J Cell Biol, 2001 Apr 16. PMID 11309411, Free PMC Article
  2. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC95296

Gene Ontology Provided by RGD

Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
tetraspanin-3
Names
transmembrane 4 superfamily member 8
NP_001005547.1
XP_063121188.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005547.1 → NP_001005547.1  tetraspanin-3

    See identical proteins and their annotated locations for NP_001005547.1

    Status: PROVISIONAL

    Source sequence(s)
    BC082102
    UniProtKB/TrEMBL
    A0A8I6GLN5, F7F5Z9, Q66H06
    Related
    ENSRNOP00000022419.4, ENSRNOT00000022419.6
    Conserved Domains (2) summary
    cd03163
    Location:104 → 210
    TM4SF8_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF8_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:10 → 237
    Tetraspannin; Tetraspanin family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    65442100..65465961 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063265118.1 → XP_063121188.1  tetraspanin-3 isoform X1

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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