U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Parp6 poly (ADP-ribose) polymerase family, member 6 [ Rattus norvegicus (Norway rat) ]

Gene ID: 300759, updated on 9-Jul-2024

Summary

Go to the top of the page Help
Official Symbol
Parp6provided by RGD
Official Full Name
poly (ADP-ribose) polymerase family, member 6provided by RGD
Primary source
RGD:1310937
See related
Ensembl:ENSRNOG00000011199 AllianceGenome:RGD:1310937
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1310937
Summary
Predicted to enable NAD+ ADP-ribosyltransferase activity and protein ADP-ribosylase activity. Involved in positive regulation of dendrite morphogenesis. Orthologous to human PARP6 (poly(ADP-ribose) polymerase family member 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 168.0), Muscle (RPKM 109.1) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Parp6 in Genome Data Viewer
Location:
8q24
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (68912393..68944904)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (60016594..60049108)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (64439933..64472443)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 202 Neighboring gene hexosaminidase subunit alpha Neighboring gene CUGBP, Elav-like family member 6 Neighboring gene U4 spliceosomal RNA Neighboring gene pyruvate kinase M1/2 Neighboring gene GRAM domain containing 2A

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. PARP6 is a Regulator of Hippocampal Dendritic Morphogenesis. Huang JY, et al. Sci Rep, 2016 Jan 4. PMID 26725726, Free PMC Article
  2. Structures and Mechanisms of Enzymes Employed in the Synthesis and Degradation of PARP-Dependent Protein ADP-Ribosylation. Barkauskaite E, et al. Mol Cell, 2015 Jun 18. PMID 26091342
  3. Family-wide analysis of poly(ADP-ribose) polymerase activity. Vyas S, et al. Nat Commun, 2014 Jul 21. PMID 25043379, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables NAD+ ADP-ribosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables NAD+- protein-aspartate ADP-ribosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables NAD+- protein-cysteine ADP-ribosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in endoplasmic reticulum unfolded protein response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of dendrite morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein auto-ADP-ribosylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum tubular network IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nuclear envelope IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
protein mono-ADP-ribosyltransferase PARP6
Names
poly [ADP-ribose] polymerase 6
NP_001100298.1
XP_006243253.2
XP_008764454.1
XP_008764455.1
XP_038937032.1
XP_038937033.1
XP_063121204.1
XP_063121205.1
XP_063121206.1
XP_063121207.1
XP_063121208.1
XP_063121209.1
XP_063121210.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106828.1 → NP_001100298.1  protein mono-ADP-ribosyltransferase PARP6

    See identical proteins and their annotated locations for NP_001100298.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473975
    UniProtKB/TrEMBL
    A6J529
    Conserved Domains (1) summary
    cd01341
    Location:470 → 594
    ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    68912393..68944904
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039081105.1 → XP_038937033.1  protein mono-ADP-ribosyltransferase PARP6 isoform X1

    UniProtKB/TrEMBL
    G3V9P8
    Conserved Domains (1) summary
    cd01341
    Location:471 → 595
    ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...

  2. XM_063265136.1 → XP_063121206.1  protein mono-ADP-ribosyltransferase PARP6 isoform X2

    UniProtKB/TrEMBL
    A6J529

  3. XM_006243191.2 → XP_006243253.2  protein mono-ADP-ribosyltransferase PARP6 isoform X1

    UniProtKB/TrEMBL
    G3V9P8
    Conserved Domains (1) summary
    cd01341
    Location:471 → 595
    ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...

  4. XM_008766232.3 → XP_008764454.1  protein mono-ADP-ribosyltransferase PARP6 isoform X3

    Conserved Domains (1) summary
    cd01341
    Location:451 → 575
    ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...

  5. XM_008766233.3 → XP_008764455.1  protein mono-ADP-ribosyltransferase PARP6 isoform X4

    Related
    ENSRNOP00000055141.5, ENSRNOT00000058339.5
    Conserved Domains (1) summary
    cd01341
    Location:450 → 574
    ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...

  6. XM_039081104.1 → XP_038937032.1  protein mono-ADP-ribosyltransferase PARP6 isoform X1

    UniProtKB/TrEMBL
    G3V9P8
    Conserved Domains (1) summary
    cd01341
    Location:471 → 595
    ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...

  7. XM_063265134.1 → XP_063121204.1  protein mono-ADP-ribosyltransferase PARP6 isoform X1

    UniProtKB/TrEMBL
    G3V9P8

  8. XM_063265137.1 → XP_063121207.1  protein mono-ADP-ribosyltransferase PARP6 isoform X5

    UniProtKB/TrEMBL
    A0A8I5ZUL8

  9. XM_063265138.1 → XP_063121208.1  protein mono-ADP-ribosyltransferase PARP6 isoform X6

    UniProtKB/TrEMBL
    A0A8I5ZUL8, A0A8I6GHS7

  10. XM_063265139.1 → XP_063121209.1  protein mono-ADP-ribosyltransferase PARP6 isoform X7

    UniProtKB/TrEMBL
    B2RZ49
    Related
    ENSRNOP00000094761.2, ENSRNOT00000119643.2

  11. XM_063265140.1 → XP_063121210.1  protein mono-ADP-ribosyltransferase PARP6 isoform X8

    UniProtKB/TrEMBL
    A0A8I5ZUL8, A0A8I6A4Q9
    Related
    ENSRNOP00000086132.2, ENSRNOT00000105803.2

  12. XM_063265135.1 → XP_063121205.1  protein mono-ADP-ribosyltransferase PARP6 isoform X1

    UniProtKB/TrEMBL
    G3V9P8
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools