Coro2b coronin 2B [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Coro2bprovided by RGD
Official Full Name: coronin 2Bprovided by RGD
Primary source: RGD:1561953
See related: EnsemblRapid:ENSRNOG00000015257 AllianceGenome:RGD:1561953
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable actin filament binding activity; talin binding activity; and vinculin binding activity. Predicted to act upstream of or within several processes, including focal adhesion assembly; negative regulation of stress fiber assembly; and regulation of establishment of protein localization. Predicted to be located in focal adhesion. Orthologous to human CORO2B (coronin 2B). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Thymus (RPKM 66.8), Brain (RPKM 62.6) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q24

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (71802329..71912739, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (62906861..63017295, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (67374617..67492490, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI227762 (e-PCR)
- UniSTS:250462

D8Rat95 (e-PCR)
- UniSTS:119141

D8Rat212 (e-PCR), detects polymorphism
- UniSTS:228278

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables talin binding	ISO Inferred from Sequence Orthology more info
enables vinculin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within focal adhesion assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of cell-substrate adhesion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of establishment of protein localization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of stress fiber assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of establishment of protein localization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cellular response to stress	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of glomerular filtration	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in focal adhesion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: coronin-2B

Names: coronin, actin binding protein, 2B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.