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Tmod3 tropomodulin 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 300838, updated on 17-Aug-2024

Summary

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Official Symbol
Tmod3provided by RGD
Official Full Name
tropomodulin 3provided by RGD
Primary source
RGD:1311030
See related
EnsemblRapid:ENSRNOG00000032436 AllianceGenome:RGD:1311030
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable tropomyosin binding activity. Predicted to be involved in actin filament organization; muscle contraction; and myofibril assembly. Predicted to act upstream of or within actin cytoskeleton organization; erythrocyte development; and positive regulation of mitotic cell cycle phase transition. Predicted to be active in striated muscle thin filament. Orthologous to human TMOD3 (tropomodulin 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 442.1), Heart (RPKM 319.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tmod3 in Genome Data Viewer
Location:
8q24
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (85131295..85191477, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (76248978..76310855, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (82432165..82492243, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene LEO1 homolog, Paf1/RNA polymerase II complex component Neighboring gene RNA polymerase-associated protein LEO1-like Neighboring gene uncharacterized LOC134480207 Neighboring gene tropomodulin 2 Neighboring gene LysM domain containing 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Tropomodulin3-null mice are embryonic lethal with anemia due to impaired erythroid terminal differentiation in the fetal liver. Sui Z, et al. Blood, 2014 Jan 30. PMID 24159174, Free PMC Article
  2. Tropomodulin isoforms regulate thin filament pointed-end capping and skeletal muscle physiology. Gokhin DS, et al. J Cell Biol, 2010 Apr 5. PMID 20368620, Free PMC Article
  3. Phosphorylation and degradation of tomosyn-2 de-represses insulin secretion. Bhatnagar S, et al. J Biol Chem, 2014 Sep 5. PMID 25002582, Free PMC Article
  4. Interactome analysis of AMP-activated protein kinase (AMPK)-α1 and -β1 in INS-1 pancreatic beta-cells by affinity purification-mass spectrometry. Moon S, et al. Sci Rep, 2014 Mar 14. PMID 24625528, Free PMC Article
  5. E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Guo Z, et al. Sci Signal, 2014 Dec 2. PMID 25468996, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables tropomyosin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tropomyosin binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within erythrocyte development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of mitotic cell cycle phase transition ISO
Inferred from Sequence Orthology
more info
  
involved_in muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in myofibril assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in pointed-end actin filament capping IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of mitotic cell cycle phase transition ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in myofibril IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in striated muscle thin filament IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in striated muscle thin filament ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
tropomodulin-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001011997.1 → NP_001011997.1  tropomodulin-3

    See identical proteins and their annotated locations for NP_001011997.1

    Status: PROVISIONAL

    Source sequence(s)
    BC079290
    UniProtKB/TrEMBL
    A0A8I6GJC0, A6I1D5, F7F0R0, Q6AXW2
    Related
    ENSRNOP00000111996.1, ENSRNOT00000155874.1
    Conserved Domains (2) summary
    cd00116
    Location:216 → 292
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    pfam03250
    Location:5 → 144
    Tropomodulin; Tropomodulin

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    85131295..85191477 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063265181.1 → XP_063121251.1  tropomodulin-3 isoform X1

    UniProtKB/TrEMBL
    A0A8I6GJC0, A6I1D5, F7F0R0, Q6AXW2

  2. XM_039081147.2 → XP_038937075.1  tropomodulin-3 isoform X2

    Conserved Domains (1) summary
    cl39015
    Location:77 → 153
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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