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Cep63 centrosomal protein 63 [ Rattus norvegicus (Norway rat) ]

Gene ID: 300963, updated on 2-Nov-2024

Summary

Official Symbol
Cep63provided by RGD
Official Full Name
centrosomal protein 63provided by RGD
Primary source
RGD:1561183
See related
EnsemblRapid:ENSRNOG00000008410 AllianceGenome:RGD:1561183
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable molecular adaptor activity. Predicted to be involved in several processes, including negative regulation of protein K63-linked ubiquitination; non-membrane-bounded organelle assembly; and protein stabilization. Predicted to act upstream of or within several processes, including centrosome duplication; meiosis I; and negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator. Predicted to be located in centrosome and spindle pole. Predicted to be active in centriole. Human ortholog(s) of this gene implicated in Seckel syndrome 6. Orthologous to human CEP63 (centrosomal protein 63). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Testes (RPKM 178.4), Thymus (RPKM 61.0) and 9 other tissues See more
Orthologs
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Genomic context

See Cep63 in Genome Data Viewer
Location:
8q32
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (112041586..112093061, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (103162639..103214177, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (111063988..111116014, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene kyphoscoliosis peptidase Neighboring gene ribosomal protein L27, pseudogene 3 Neighboring gene anaphase promoting complex subunit 13 Neighboring gene uncharacterized LOC134480096 Neighboring gene angiomotin like 2

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from PubChem

General gene information

Markers

Clone Names

  • MGC114577

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables molecular adaptor activity IEA
Inferred from Electronic Annotation
more info
 
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in DNA damage checkpoint signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in centriole replication IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in centriole replication IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within centriole replication ISO
Inferred from Sequence Orthology
more info
 
involved_in centriole replication ISO
Inferred from Sequence Orthology
more info
 
involved_in centriole replication ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within centrosome duplication ISO
Inferred from Sequence Orthology
more info
 
involved_in de novo centriole assembly involved in multi-ciliated epithelial cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of intrinsic apoptotic signaling pathway by p53 class mediator ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within meiotic telomere clustering ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of innate immune response ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein K63-linked ubiquitination IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of protein K63-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein K63-linked ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within protein localization to centrosome ISO
Inferred from Sequence Orthology
more info
 
involved_in protein stabilization IEA
Inferred from Electronic Annotation
more info
 
involved_in protein stabilization ISO
Inferred from Sequence Orthology
more info
 
involved_in protein stabilization ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within reciprocal meiotic recombination ISO
Inferred from Sequence Orthology
more info
 
involved_in signal transduction in response to DNA damage ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in spindle assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in centriolar satellite IEA
Inferred from Electronic Annotation
more info
 
is_active_in centriole IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in centriole ISO
Inferred from Sequence Orthology
more info
 
located_in centriole ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in centrosome ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in spindle pole ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
centrosomal protein of 63 kDa
Names
centrosomal protein 63kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037772.1NP_001032861.2  centrosomal protein of 63 kDa isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer protein (isoform 1).
    Source sequence(s)
    BC098948
    UniProtKB/TrEMBL
    A0A096MIU4, A6I2H5
    Conserved Domains (1) summary
    pfam17045
    Location:56318
    CEP63; Centrosomal protein of 63 kDa
  2. NM_001244805.1NP_001231734.1  centrosomal protein of 63 kDa isoform 2

    See identical proteins and their annotated locations for NP_001231734.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains a different segment for its 5' end which results in the use of a downstream start codon, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.
    Source sequence(s)
    BC161815
    UniProtKB/Swiss-Prot
    Q4KLY0
    UniProtKB/TrEMBL
    A6I2H5
    Related
    ENSRNOP00000092635.1, ENSRNOT00000114079.2
    Conserved Domains (1) summary
    pfam17045
    Location:18280
    CEP63; Centrosomal protein of 63 kDa

RNA

  1. NR_045200.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    BC083632

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    112041586..112093061 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039081193.2XP_038937121.1  centrosomal protein of 63 kDa isoform X1

    UniProtKB/TrEMBL
    A0A0G2JXF3
    Conserved Domains (2) summary
    pfam15921
    Location:29612
    CCDC158; Coiled-coil domain-containing protein 158
    pfam17045
    Location:47309
    CEP63; Centrosomal protein of 63 kDa
  2. XM_017595591.3XP_017451080.2  centrosomal protein of 63 kDa isoform X3

    Conserved Domains (2) summary
    COG1196
    Location:3397
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam17045
    Location:1189
    CEP63; Centrosomal protein of 63 kDa
  3. XM_039081195.2XP_038937123.1  centrosomal protein of 63 kDa isoform X2

    Conserved Domains (2) summary
    pfam15921
    Location:1583
    CCDC158; Coiled-coil domain-containing protein 158
    pfam17045
    Location:18280
    CEP63; Centrosomal protein of 63 kDa
  4. XM_039081196.2XP_038937124.1  centrosomal protein of 63 kDa isoform X2

    Conserved Domains (2) summary
    pfam15921
    Location:1583
    CCDC158; Coiled-coil domain-containing protein 158
    pfam17045
    Location:18280
    CEP63; Centrosomal protein of 63 kDa
  5. XM_039081191.2XP_038937119.1  centrosomal protein of 63 kDa isoform X1

    UniProtKB/TrEMBL
    A0A0G2JXF3
    Related
    ENSRNOP00000070249.3, ENSRNOT00000084413.3
    Conserved Domains (2) summary
    pfam15921
    Location:29612
    CCDC158; Coiled-coil domain-containing protein 158
    pfam17045
    Location:47309
    CEP63; Centrosomal protein of 63 kDa
  6. XM_039081199.2XP_038937127.1  centrosomal protein of 63 kDa isoform X4

    UniProtKB/TrEMBL
    A6I2H5
    Related
    ENSRNOP00000029550.6, ENSRNOT00000031313.8
    Conserved Domains (2) summary
    TIGR02168
    Location:165492
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam17045
    Location:47309
    CEP63; Centrosomal protein of 63 kDa
  7. XM_063265227.1XP_063121297.1  centrosomal protein of 63 kDa isoform X1

    UniProtKB/TrEMBL
    A0A0G2JXF3
    Related
    ENSRNOP00000083027.2, ENSRNOT00000099786.2
  8. XM_063265229.1XP_063121299.1  centrosomal protein of 63 kDa isoform X5