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Srprb SRP receptor subunit beta [ Rattus norvegicus (Norway rat) ]

Gene ID: 300965, updated on 5-Mar-2024

Summary

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Official Symbol
Srprbprovided by RGD
Official Full Name
SRP receptor subunit betaprovided by RGD
Primary source
RGD:1304698
See related
AllianceGenome:RGD:1304698
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Cc1-8; Ab2-417; Ba1-667
Summary
Enables ubiquitin protein ligase binding activity. Predicted to be involved in protein targeting to ER. Predicted to be located in cytoplasmic microtubule and membrane. Predicted to be part of signal recognition particle receptor complex. Orthologous to human SRPRB (SRP receptor subunit beta). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 337.8), Kidney (RPKM 250.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Srprb in Genome Data Viewer
Location:
8q32
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (112647577..112661524, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (103768685..103782632, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (111673479..111687426, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene solute carrier organic anion transporter family, member 2a1 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene RAB6B, member RAS oncogene family Neighboring gene uncharacterized LOC134480222 Neighboring gene uncharacterized LOC134480223 Neighboring gene uncharacterized LOC134480224 Neighboring gene transferrin Neighboring gene uncharacterized LOC120094247

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Subcellular localization of APMCF1 and its biological significance of expression pattern in normal and malignant human tissues. Zhang Y, et al. J Exp Clin Cancer Res, 2009 Aug 9. PMID 19664239, Free PMC Article
  2. Pirh2 interacts with and ubiquitylates signal recognition particle receptor beta subunit. Abe K, et al. Biomed Res, 2008 Feb. PMID 18344599
  3. MTR120/KIAA1383, a novel microtubule-associated protein, promotes microtubule stability and ensures cytokinesis. Fong KW, et al. J Cell Sci, 2013 Feb 1. PMID 23264731, Free PMC Article
  4. Different effects of Sec61α, Sec62 and Sec63 depletion on transport of polypeptides into the endoplasmic reticulum of mammalian cells. Lang S, et al. J Cell Sci, 2012 Apr 15. PMID 22375059, Free PMC Article
  5. Phosphorylation and degradation of tomosyn-2 de-represses insulin secretion. Bhatnagar S, et al. J Biol Chem, 2014 Sep 5. PMID 25002582, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Potential readthrough

Included gene: Tf

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein targeting to ER IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic microtubule ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic microtubule ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
part_of signal recognition particle receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of signal recognition particle receptor complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
signal recognition particle receptor subunit beta
Names
SR-beta
SRP receptor beta subunit
signal recognition particle receptor, B subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013252.1 → NP_001013270.1  signal recognition particle receptor subunit beta

    See identical proteins and their annotated locations for NP_001013270.1

    Status: VALIDATED

    Source sequence(s)
    BF523222, BF525252, BQ204036
    UniProtKB/Swiss-Prot
    Q4FZX7
    UniProtKB/TrEMBL
    A6I2I7
    Conserved Domains (1) summary
    pfam09439
    Location:60 → 239
    SRPRB; Signal recognition particle receptor beta subunit

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    112647577..112661524 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q4FZX7.1 GenPept UniProtKB/Swiss-Prot:Q4FZX7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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