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Abhd14a abhydrolase domain containing 14A [ Rattus norvegicus (Norway rat) ]

Gene ID: 300982, updated on 2-Nov-2024

Summary

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Official Symbol
Abhd14aprovided by RGD
Official Full Name
abhydrolase domain containing 14Aprovided by RGD
Primary source
RGD:1309721
See related
EnsemblRapid:ENSRNOG00000011936 AllianceGenome:RGD:1309721
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Dorz1; RGD1309721
Summary
Predicted to enable hydrolase activity. Predicted to be located in membrane. Predicted to be active in cytoplasm. Orthologous to human ABHD14A (abhydrolase domain containing 14A). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 122.8), Adrenal (RPKM 31.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Abhd14a in Genome Data Viewer
Location:
8q32
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (115957853..115965697, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (107079139..107089004, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (115141575..115151222, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L29 Neighboring gene uncharacterized LOC134480228 Neighboring gene dual specificity phosphatase 7 Neighboring gene abhydrolase domain containing 14b Neighboring gene aminoacylase 1 Neighboring gene poly(rC) binding protein 4 Neighboring gene G protein-coupled receptor 62

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Dorz1, a novel gene expressed in differentiating cerebellar granule neurons, is down-regulated in Zic1-deficient mouse. Hoshino J, et al. Brain Res Mol Brain Res, 2003 Dec 12. PMID 14667578
  2. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC95137

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein ABHD14A
Names
abhydrolase domain-containing protein 14A
alpha/beta hydrolase domain-containing protein 14A
down-regulated in Zic1 deficient cerebellar primordium

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001009670.1 → NP_001009670.1  protein ABHD14A

    See identical proteins and their annotated locations for NP_001009670.1

    Status: PROVISIONAL

    Source sequence(s)
    BC088472
    UniProtKB/Swiss-Prot
    Q5I0C4
    UniProtKB/TrEMBL
    A0A8L2Q7K3, A6I2R8
    Related
    ENSRNOP00000016056.8, ENSRNOT00000016056.8
    Conserved Domains (1) summary
    COG0596
    Location:45 → 241
    MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    115957853..115965697 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008766499.4 → XP_008764721.1  protein ABHD14A isoform X1

    Conserved Domains (2) summary
    COG0596
    Location:45 → 138
    MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
    pfam12695
    Location:68 → 177
    Abhydrolase_5; Alpha/beta hydrolase family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5I0C4.1 GenPept UniProtKB/Swiss-Prot:Q5I0C4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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