Mst1r macrophage stimulating 1 receptor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mst1rprovided by RGD
Official Full Name: macrophage stimulating 1 receptorprovided by RGD
Primary source: RGD:1306465
See related: EnsemblRapid:ENSRNOG00000032618 AllianceGenome:RGD:1306465
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ron; Stk; Ptk8; Cdw136
Summary: Predicted to enable enzyme binding activity and transmembrane receptor protein tyrosine kinase activity. Predicted to be involved in several processes, including cell surface receptor protein tyrosine kinase signaling pathway; phagocytosis; and positive regulation of intracellular signal transduction. Predicted to act upstream of or within response to virus. Predicted to be located in stress fiber and vacuole. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in nasopharynx carcinoma. Orthologous to human MST1R (macrophage stimulating 1 receptor). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Heart (RPKM 28.1), Lung (RPKM 18.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q32

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (117471928..117491059)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (108596100..108611441)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (116686601..116700132)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MSP and its receptor RON are involved in the smoke-induced airway inflammation in rats
Title: Roles of macrophage stimulating protein and tyrosine kinase receptor RON in smoke-induced airway inflammation of rats.
Mesenchymal stromal cells increased serum and tissue HGF levels, Met tubular expression and prevented the suppression of tubular MSP/RON expression.
Title: Mesenchymal stromal cells reset the scatter factor system and cytokine network in experimental kidney transplantation.
A pathogenic role of the MSP/RON system in anti-Thy 1 nephritis.
Title: Neutralization of macrophage-stimulating protein ameliorates renal injury in anti-thy 1 glomerulonephritis.
Met is present in clusters that strongly colocalize with the NR2B subunit of the N-methyl-D-aspartate receptor, PSD-95 and synapsin at excitatory synapses of hippocampal neurons
Title: The receptor tyrosine kinase Met and its ligand hepatocyte growth factor are clustered at excitatory synapses and can enhance clustering of synaptic proteins.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables transmembrane receptor protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in multicellular organism development	IBA Inferred from Biological aspect of Ancestor more info
involved_in nervous system development	IBA Inferred from Biological aspect of Ancestor more info
involved_in phagocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of MAP kinase activity	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of MAP kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of plasma membrane bounded cell projection organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to virus	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info
located_in stress fiber	ISO Inferred from Sequence Orthology more info
located_in vacuole	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: macrophage-stimulating protein receptor

Names: macrophage stimulating 1 receptor (c-met-related tyrosine kinase); protein tyrosine kinase 8; receptor protein tyrosine kinase, c-met-related

NP_001100325.2

EC 2.7.10.1

NP_001399128.1

EC 2.7.10.1

XP_038937153.1

EC 2.7.10.1

XP_038937156.1

EC 2.7.10.1

XP_063121316.1

EC 2.7.10.1

XP_063121317.1

EC 2.7.10.1

XP_063121318.1

EC 2.7.10.1

XP_063121319.1

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106855.4 → NP_001100325.2 macrophage-stimulating protein receptor isoform 2 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/TrEMBL

D3ZYM4

Related

ENSRNOP00000063136.3, ENSRNOT00000066104.4

Conserved Domains (7) summary

cd11279
Location:29 → 521

Sema_RON; The Sema domain, a protein interacting module, of RON Receptor Tyrosine Kinase

smart00429
Location:767 → 828

IPT; ig-like, plexins, transcription factors

cd01179
Location:682 → 766

IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd05058
Location:1058 → 1319

PTKc_Met_Ron; Catalytic domain of the Protein Tyrosine Kinases, Met and Ron

pfam01437
Location:524 → 563

PSI; Plexin repeat

pfam07714
Location:1054 → 1310

Pkinase_Tyr; Protein tyrosine kinase

cl15674
Location:567 → 681

IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
NM_001412199.2 → NP_001399128.1 macrophage-stimulating protein receptor isoform 1 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/TrEMBL

A0A8I6A5T6

Related

ENSRNOP00000101158.1, ENSRNOT00000131833.1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

117471928..117491059

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063265246.1 → XP_063121316.1 macrophage-stimulating protein receptor isoform X1
XM_063265247.1 → XP_063121317.1 macrophage-stimulating protein receptor isoform X2
XM_063265249.1 → XP_063121319.1 macrophage-stimulating protein receptor isoform X5
XM_039081228.2 → XP_038937156.1 macrophage-stimulating protein receptor isoform X6

Conserved Domains (6) summary

cd11279
Location:29 → 521

Sema_RON; The Sema domain, a protein interacting module, of RON Receptor Tyrosine Kinase

smart00429
Location:767 → 828

IPT; ig-like, plexins, transcription factors

cd01179
Location:682 → 766

IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd05058
Location:1084 → 1345

PTKc_Met_Ron; Catalytic domain of the Protein Tyrosine Kinases, Met and Ron

pfam01437
Location:524 → 566

PSI; Plexin repeat

cl15674
Location:567 → 681

IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
XM_039081225.2 → XP_038937153.1 macrophage-stimulating protein receptor isoform X3

Conserved Domains (6) summary

cd11279
Location:29 → 521

Sema_RON; The Sema domain, a protein interacting module, of RON Receptor Tyrosine Kinase

smart00429
Location:767 → 828

IPT; ig-like, plexins, transcription factors

cd01179
Location:682 → 766

IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

pfam01437
Location:524 → 566

PSI; Plexin repeat

cl15674
Location:567 → 681

IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...

cl21453
Location:1076 → 1364

PKc_like; Protein Kinases, catalytic domain
XM_063265248.1 → XP_063121318.1 macrophage-stimulating protein receptor isoform X4