P4htm prolyl 4-hydroxylase, transmembrane [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: P4htmprovided by RGD
Official Full Name: prolyl 4-hydroxylase, transmembraneprovided by RGD
Primary source: RGD:1311848
See related: EnsemblRapid:ENSRNOG00000020249 AllianceGenome:RGD:1311848
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ph-4; RGD1311848
Summary: Predicted to enable procollagen-proline 4-dioxygenase activity. Predicted to be involved in peptidyl-proline hydroxylation to 4-hydroxy-L-proline. Predicted to act upstream of or within regulation of erythrocyte differentiation. Predicted to be integral component of membrane. Predicted to be active in endoplasmic reticulum. Orthologous to human P4HTM (prolyl 4-hydroxylase, transmembrane). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 122.5), Heart (RPKM 98.8) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q32

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (118153158..118172199, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (109274629..109292802, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (117364895..117383275, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

NoName (e-PCR)
- UniSTS:490814

AI853847 (e-PCR)
- UniSTS:164420

BB128974 (e-PCR)
- UniSTS:185807

RH128647 (e-PCR)
- UniSTS:211955

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 2-oxoglutarate-dependent dioxygenase activity	ISO Inferred from Sequence Orthology more info
enables L-ascorbic acid binding	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables procollagen-proline 4-dioxygenase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in peptidyl-proline hydroxylation to 4-hydroxy-L-proline	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of erythrocyte differentiation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: transmembrane prolyl 4-hydroxylase

Names: hypoxia-inducible factor prolyl 4-hydroxylase

NP_001386206.1

EC 1.14.11.29

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001399277.1 → NP_001386206.1 transmembrane prolyl 4-hydroxylase

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/TrEMBL

A6I372, D3ZJG3

Related

ENSRNOP00000027466.5, ENSRNOT00000027466.8

Conserved Domains (2) summary

smart00702
Location:247 → 459

P4Hc; Prolyl 4-hydroxylase alpha subunit homologues

pfam13499
Location:193 → 253

EF-hand_7; EF-hand domain pair