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Cmtm8 CKLF-like MARVEL transmembrane domain containing 8 [ Rattus norvegicus (Norway rat) ]

Gene ID: 301045, updated on 17-Aug-2024

Summary

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Official Symbol
Cmtm8provided by RGD
Official Full Name
CKLF-like MARVEL transmembrane domain containing 8provided by RGD
Primary source
RGD:735040
See related
EnsemblRapid:ENSRNOG00000011201 AllianceGenome:RGD:735040
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Cklfsf8
Summary
Predicted to be a structural constituent of myelin sheath. Predicted to be involved in myelination. Predicted to be located in nucleoplasm. Predicted to be integral component of membrane. Orthologous to human CMTM8 (CKLF like MARVEL transmembrane domain containing 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 88.1), Lung (RPKM 87.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Cmtm8 in Genome Data Viewer
Location:
8q32
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (123360168..123425291, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (114481730..114547107, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (122848249..122913597, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene CKLF-like MARVEL transmembrane domain containing 6 Neighboring gene CKLF-like MARVEL transmembrane domain containing 7 Neighboring gene uncharacterized LOC134480243 Neighboring gene U6 spliceosomal RNA Neighboring gene glycerol-3-phosphate dehydrogenase 1 like Neighboring gene oxysterol binding protein-like 10 Neighboring gene uncharacterized LOC108351789

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification of eight genes encoding chemokine-like factor superfamily members 1-8 (CKLFSF1-8) by in silico cloning and experimental validation. Han W, et al. Genomics, 2003 Jun. PMID 12782130
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC108531

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables structural constituent of myelin sheath IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in myelination IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
CKLF-like MARVEL transmembrane domain-containing protein 8
Names
chemokine-like factor super family 8
chemokine-like related protein 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198754.2 → NP_942049.1  CKLF-like MARVEL transmembrane domain-containing protein 8

    See identical proteins and their annotated locations for NP_942049.1

    Status: PROVISIONAL

    Source sequence(s)
    BC088094
    UniProtKB/TrEMBL
    F7F866, Q71B06
    Related
    ENSRNOP00000015188.4, ENSRNOT00000015188.6
    Conserved Domains (1) summary
    pfam01284
    Location:36 → 162
    MARVEL; Membrane-associating domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    123360168..123425291 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063265301.1 → XP_063121371.1  CKLF-like MARVEL transmembrane domain-containing protein 8 isoform X3

  2. XM_006243964.5 → XP_006244026.1  CKLF-like MARVEL transmembrane domain-containing protein 8 isoform X1

    UniProtKB/TrEMBL
    A0A8I5Y7X1
    Related
    ENSRNOP00000077565.1, ENSRNOT00000101305.2
    Conserved Domains (1) summary
    pfam01284
    Location:44 → 156
    MARVEL; Membrane-associating domain

  3. XM_063265300.1 → XP_063121370.1  CKLF-like MARVEL transmembrane domain-containing protein 8 isoform X2

  4. XM_063265302.1 → XP_063121372.1  CKLF-like MARVEL transmembrane domain-containing protein 8 isoform X4

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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