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Slc25a38 solute carrier family 25, member 38 [ Rattus norvegicus (Norway rat) ]

Gene ID: 301067, updated on 19-Sep-2024

Summary

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Official Symbol
Slc25a38provided by RGD
Official Full Name
solute carrier family 25, member 38provided by RGD
Primary source
RGD:1311914
See related
EnsemblRapid:ENSRNOG00000018552 AllianceGenome:RGD:1311914
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1311914
Summary
Predicted to enable glycine transmembrane transporter activity. Predicted to be involved in erythrocyte differentiation and glycine import into mitochondrion. Predicted to be located in mitochondrial inner membrane. Predicted to be integral component of membrane. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in autosomal recessive pyridoxine-refractory sideroblastic anemia 2. Orthologous to human SLC25A38 (solute carrier family 25 member 38). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 83.3), Spleen (RPKM 57.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Slc25a38 in Genome Data Viewer
Location:
8q32
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (128713180..128725968)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (119835546..119848334)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (128790348..128802988)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480114 Neighboring gene C-X3-C motif chemokine receptor 1 Neighboring gene C-C motif chemokine receptor 8 Neighboring gene small nucleolar RNA, H/ACA box 73B like 1 Neighboring gene small nucleolar RNA, H/ACA box 6 Neighboring gene ribosomal protein SA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Characterization of Human and Yeast Mitochondrial Glycine Carriers with Implications for Heme Biosynthesis and Anemia. Lunetti P, et al. J Biol Chem, 2016 Sep 16. PMID 27476175, Free PMC Article
  2. Mutations in mitochondrial carrier family gene SLC25A38 cause nonsyndromic autosomal recessive congenital sideroblastic anemia. Guernsey DL, et al. Nat Genet, 2009 Jun. PMID 19412178
  3. Synthesis, delivery and regulation of eukaryotic heme and Fe-S cluster cofactors. Barupala DP, et al. Arch Biochem Biophys, 2016 Feb 15. PMID 26785297, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC124671

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables glycine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glycine transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables glycine transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in erythrocyte differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in erythrocyte differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in erythrocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in glycine import into mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycine import into mitochondrion IEA
Inferred from Electronic Annotation
more info
  
involved_in glycine import into mitochondrion ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial inner membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
mitochondrial glycine transporter

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001030032.2 → NP_001025203.2  mitochondrial glycine transporter

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/Swiss-Prot
    G3V8E7, Q499U1
    UniProtKB/TrEMBL
    A0A8L2QD79
    Related
    ENSRNOP00000025142.6, ENSRNOT00000025142.8
    Conserved Domains (1) summary
    pfam00153
    Location:46 → 137
    Mito_carr; Mitochondrial carrier protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    128713180..128725968
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039081302.2 → XP_038937230.1  mitochondrial glycine transporter isoform X2

    Conserved Domains (1) summary
    pfam00153
    Location:51 → 134
    Mito_carr; Mitochondrial carrier protein

  2. XM_006244089.5 → XP_006244151.1  mitochondrial glycine transporter isoform X1

    UniProtKB/TrEMBL
    A0A0G2K0U7, A0A8L2QD79
    Related
    ENSRNOP00000071588.1, ENSRNOT00000083329.3
    Conserved Domains (2) summary
    PTZ00169
    Location:30 → 297
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
    pfam00153
    Location:25 → 116
    Mito_carr; Mitochondrial carrier protein

  3. XM_039081301.2 → XP_038937229.1  mitochondrial glycine transporter isoform X2

    Conserved Domains (1) summary
    pfam00153
    Location:51 → 134
    Mito_carr; Mitochondrial carrier protein

  4. XM_039081304.2 → XP_038937232.1  mitochondrial glycine transporter isoform X3

    UniProtKB/TrEMBL
    A6I3Z2
    Conserved Domains (1) summary
    pfam00153
    Location:89 → 176
    Mito_carr; Mitochondrial carrier protein

  5. XM_039081305.2 → XP_038937233.1  mitochondrial glycine transporter isoform X3

    UniProtKB/TrEMBL
    A6I3Z2
    Conserved Domains (1) summary
    pfam00153
    Location:89 → 176
    Mito_carr; Mitochondrial carrier protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q499U1.2 GenPept UniProtKB/Swiss-Prot:Q499U1

Gene LinkOut

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