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Prim2 DNA primase subunit 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 301323, updated on 2-Nov-2024

Summary

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Official Symbol
Prim2provided by RGD
Official Full Name
DNA primase subunit 2provided by RGD
Primary source
RGD:631433
See related
EnsemblRapid:ENSRNOG00000012486 AllianceGenome:RGD:631433
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Pola3
Summary
Predicted to enable 4 iron, 4 sulfur cluster binding activity and DNA/RNA hybrid binding activity. Predicted to be involved in DNA replication initiation; DNA replication, synthesis of primer; and positive regulation of DNA primase activity. Predicted to be part of alpha DNA polymerase:primase complex. Orthologous to human PRIM2 (DNA primase subunit 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 108.9), Testes (RPKM 101.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Prim2 in Genome Data Viewer
Location:
9q21
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (43188350..43400482, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (35692376..35904521, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (38535435..38745058)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene SWI5 homologous recombination repair protein, pseudogene 1 Neighboring gene telomerase RNA component interacting RNase, pseudogene 2 Neighboring gene cofilin-2, pseudogene 2 Neighboring gene RAB23, member RAS oncogene family

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A mutation in subunit B of the DNA polymerase alpha-primase complex from Novikoff hepatoma cells concomitant with a conformational change and abnormal catalytic properties of the DNA polymerase alpha-primase complex. Popanda O, et al. Mol Carcinog, 2001 Aug. PMID 11536367
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables 4 iron, 4 sulfur cluster binding ISO
Inferred from Sequence Orthology
more info
  
enables 4 iron, 4 sulfur cluster binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA/RNA hybrid binding ISO
Inferred from Sequence Orthology
more info
  
enables DNA/RNA hybrid binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA replication NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in DNA replication initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA replication initiation ISO
Inferred from Sequence Orthology
more info
  
involved_in DNA replication, synthesis of primer IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA replication, synthesis of primer IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA replication, synthesis of primer ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA primase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA primase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of alpha DNA polymerase:primase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of alpha DNA polymerase:primase complex IEA
Inferred from Electronic Annotation
more info
  
part_of alpha DNA polymerase:primase complex ISO
Inferred from Sequence Orthology
more info
  
part_of alpha DNA polymerase:primase complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
DNA primase large subunit
Names
DNA polymerase alpha subunit III (primase)
DNA primase 58 kDa subunit
DNA primase, p58 subunit
p58
primase (DNA) subunit 2
primase, DNA, polypeptide 2
NP_001019933.1
NP_001386112.1
NP_001386113.1
XP_006244752.1
XP_006244753.1
XP_017451824.1
XP_038939129.1
XP_038939130.1
XP_038939133.1
XP_038939134.1
XP_038939135.1
XP_063122947.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024762.1 → NP_001019933.1  DNA primase large subunit isoform 2

    See identical proteins and their annotated locations for NP_001019933.1

    Status: PROVISIONAL

    Source sequence(s)
    BC097454
    UniProtKB/TrEMBL
    Q4V8C0
    Related
    ENSRNOP00000057197.2, ENSRNOT00000060452.6
    Conserved Domains (2) summary
    cd07322
    Location:28 → 428
    PriL_PriS_Eukaryotic; Eukaryotic core primase: Large subunit, PriL
    COG2219
    Location:22 → 441
    PRI2; Eukaryotic-type DNA primase, large subunit [Replication, recombination and repair]

  2. NM_001399183.1 → NP_001386112.1  DNA primase large subunit isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/Swiss-Prot
    O89044
    UniProtKB/TrEMBL
    A6IN89
    Related
    ENSRNOP00000016828.4, ENSRNOT00000016828.10
    Conserved Domains (1) summary
    cd07322
    Location:28 → 451
    PriL_PriS_Eukaryotic; Eukaryotic core primase: Large subunit, PriL

  3. NM_001399184.1 → NP_001386113.1  DNA primase large subunit isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/Swiss-Prot
    O89044
    UniProtKB/TrEMBL
    A6IN89
    Related
    ENSRNOP00000104632.1, ENSRNOT00000170080.1
    Conserved Domains (1) summary
    cd07322
    Location:28 → 451
    PriL_PriS_Eukaryotic; Eukaryotic core primase: Large subunit, PriL

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    43188350..43400482 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017596335.3 → XP_017451824.1  DNA primase large subunit isoform X1

    UniProtKB/Swiss-Prot
    O89044
    UniProtKB/TrEMBL
    A6IN89
    Conserved Domains (1) summary
    cd07322
    Location:28 → 451
    PriL_PriS_Eukaryotic; Eukaryotic core primase: Large subunit, PriL

  2. XM_006244691.4 → XP_006244753.1  DNA primase large subunit isoform X1

    See identical proteins and their annotated locations for XP_006244753.1

    UniProtKB/Swiss-Prot
    O89044
    UniProtKB/TrEMBL
    A6IN89
    Conserved Domains (1) summary
    cd07322
    Location:28 → 451
    PriL_PriS_Eukaryotic; Eukaryotic core primase: Large subunit, PriL

  3. XM_039083201.2 → XP_038939129.1  DNA primase large subunit isoform X1

    UniProtKB/Swiss-Prot
    O89044
    UniProtKB/TrEMBL
    A6IN89
    Conserved Domains (1) summary
    cd07322
    Location:28 → 451
    PriL_PriS_Eukaryotic; Eukaryotic core primase: Large subunit, PriL

  4. XM_039083202.2 → XP_038939130.1  DNA primase large subunit isoform X1

    UniProtKB/Swiss-Prot
    O89044
    UniProtKB/TrEMBL
    A6IN89
    Conserved Domains (1) summary
    cd07322
    Location:28 → 451
    PriL_PriS_Eukaryotic; Eukaryotic core primase: Large subunit, PriL

  5. XM_006244690.5 → XP_006244752.1  DNA primase large subunit isoform X1

    See identical proteins and their annotated locations for XP_006244752.1

    UniProtKB/Swiss-Prot
    O89044
    UniProtKB/TrEMBL
    A6IN89
    Conserved Domains (1) summary
    cd07322
    Location:28 → 451
    PriL_PriS_Eukaryotic; Eukaryotic core primase: Large subunit, PriL

  6. XM_039083205.2 → XP_038939133.1  DNA primase large subunit isoform X2

    Conserved Domains (1) summary
    cd07322
    Location:1 → 327
    PriL_PriS_Eukaryotic; Eukaryotic core primase: Large subunit, PriL

  7. XM_063266877.1 → XP_063122947.1  DNA primase large subunit isoform X3

  8. XM_039083206.1 → XP_038939134.1  DNA primase large subunit isoform X4

    Conserved Domains (1) summary
    cd07322
    Location:2 → 221
    PriL_PriS_Eukaryotic; Eukaryotic core primase: Large subunit, PriL

  9. XM_039083207.2 → XP_038939135.1  DNA primase large subunit isoform X5

    Conserved Domains (1) summary
    cd07322
    Location:17 → 214
    PriL_PriS_Eukaryotic; Eukaryotic core primase: Large subunit, PriL

RNA

  1. XR_010054582.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O89044.1 GenPept UniProtKB/Swiss-Prot:O89044

Gene LinkOut

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