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Ptpn18 protein tyrosine phosphatase, non-receptor type 18 [ Rattus norvegicus (Norway rat) ]

Gene ID: 301333, updated on 10-Jul-2024

Summary

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Official Symbol
Ptpn18provided by RGD
Official Full Name
protein tyrosine phosphatase, non-receptor type 18provided by RGD
Primary source
RGD:1311586
See related
EnsemblRapid:ENSRNOG00000013415 AllianceGenome:RGD:1311586
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
PTP20
Summary
Predicted to enable non-membrane spanning protein tyrosine phosphatase activity. Predicted to be involved in peptidyl-tyrosine dephosphorylation. Predicted to act upstream of or within blastocyst formation. Predicted to be active in cytoplasm and nucleus. Orthologous to human PTPN18 (protein tyrosine phosphatase non-receptor type 18). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 227.2), Thymus (RPKM 176.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ptpn18 in Genome Data Viewer
Location:
9q21
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (44166571..44185885)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (36672325..36689963)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (40972089..40988790)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120094660 Neighboring gene transfer RNA glutamic acid (anticodon UUC) 5 Neighboring gene coiled-coil domain containing 115 Neighboring gene IMP U3 small nucleolar ribonucleoprotein 4 Neighboring gene uncharacterized LOC134480354 Neighboring gene protease, serine, 39 Neighboring gene cripto, FRL-1, cryptic family 1 Neighboring gene small nucleolar RNA, H/ACA box 51

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The catalytic region and PEST domain of PTPN18 distinctly regulate the HER2 phosphorylation and ubiquitination barcodes. Wang HM, et al. Cell Res, 2014 Sep. PMID 25081058, Free PMC Article
  2. Cloning and characterization of PTP-K1, a novel nonreceptor protein tyrosine phosphatase highly expressed in bone marrow. Huang K, et al. Oncogene, 1996 Oct 3. PMID 8875997
  3. Towards Functional Annotation of the Preimplantation Transcriptome: An RNAi Screen in Mammalian Embryos. Cui W, et al. Sci Rep, 2016 Nov 21. PMID 27869233, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC112761, MGC112828

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables non-membrane spanning protein tyrosine phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within blastocyst formation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
tyrosine-protein phosphatase non-receptor type 18
Names
protein tyrosine phosphatase 20
NP_001013129.2
XP_038939136.1
XP_038939138.1
XP_038939139.1
XP_038939141.1
XP_038939142.1
XP_038939143.1
XP_038939145.1
XP_063122948.1
XP_063122949.1
XP_063122950.1
XP_063122951.1
XP_063122952.1
XP_063122953.1
XP_063122954.1
XP_063122955.1
XP_063122956.1
XP_063122957.1
XP_063122958.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013111.2 → NP_001013129.2  tyrosine-protein phosphatase non-receptor type 18

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/TrEMBL
    A6INA1, P70602
    Related
    ENSRNOP00000079548.2, ENSRNOT00000095122.2
    Conserved Domains (1) summary
    cl28904
    Location:27 → 292
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    44166571..44185885
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063266886.1 → XP_063122956.1  tyrosine-protein phosphatase non-receptor type 18 isoform X14

  2. XM_063266878.1 → XP_063122948.1  tyrosine-protein phosphatase non-receptor type 18 isoform X1

    UniProtKB/TrEMBL
    P70602

  3. XM_063266879.1 → XP_063122949.1  tyrosine-protein phosphatase non-receptor type 18 isoform X2

    UniProtKB/TrEMBL
    P70602

  4. XM_063266880.1 → XP_063122950.1  tyrosine-protein phosphatase non-receptor type 18 isoform X3

    UniProtKB/TrEMBL
    P70602

  5. XM_039083210.2 → XP_038939138.1  tyrosine-protein phosphatase non-receptor type 18 isoform X7

    Conserved Domains (1) summary
    cl28904
    Location:27 → 298
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  6. XM_063266883.1 → XP_063122953.1  tyrosine-protein phosphatase non-receptor type 18 isoform X7

  7. XM_039083215.2 → XP_038939143.1  tyrosine-protein phosphatase non-receptor type 18 isoform X12

    Conserved Domains (1) summary
    cl28904
    Location:27 → 298
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  8. XM_039083214.2 → XP_038939142.1  tyrosine-protein phosphatase non-receptor type 18 isoform X11

    Conserved Domains (1) summary
    cl28904
    Location:27 → 298
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  9. XM_039083208.2 → XP_038939136.1  tyrosine-protein phosphatase non-receptor type 18 isoform X4

    UniProtKB/TrEMBL
    P70602
    Related
    ENSRNOP00000092277.1, ENSRNOT00000116074.2
    Conserved Domains (1) summary
    cl28904
    Location:27 → 298
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  10. XM_063266882.1 → XP_063122952.1  tyrosine-protein phosphatase non-receptor type 18 isoform X6

  11. XM_063266887.1 → XP_063122957.1  tyrosine-protein phosphatase non-receptor type 18 isoform X14

  12. XM_063266885.1 → XP_063122955.1  tyrosine-protein phosphatase non-receptor type 18 isoform X13

  13. XM_039083217.2 → XP_038939145.1  tyrosine-protein phosphatase non-receptor type 18 isoform X15

    Conserved Domains (1) summary
    cl28904
    Location:38 → 99
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  14. XM_063266881.1 → XP_063122951.1  tyrosine-protein phosphatase non-receptor type 18 isoform X5

  15. XM_063266884.1 → XP_063122954.1  tyrosine-protein phosphatase non-receptor type 18 isoform X8

  16. XM_039083211.1 → XP_038939139.1  tyrosine-protein phosphatase non-receptor type 18 isoform X9

    Conserved Domains (1) summary
    cl28904
    Location:17 → 176
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  17. XM_039083213.2 → XP_038939141.1  tyrosine-protein phosphatase non-receptor type 18 isoform X10

    Conserved Domains (1) summary
    cl28904
    Location:17 → 170
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  18. XM_063266888.1 → XP_063122958.1  tyrosine-protein phosphatase non-receptor type 18 isoform X16

    UniProtKB/TrEMBL
    Q4KM54

RNA

  1. XR_005488868.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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