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Mettl21c methyltransferase 21C, AARS1 lysine [ Rattus norvegicus (Norway rat) ]

Gene ID: 301378, updated on 18-Sep-2024

Summary

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Official Symbol
Mettl21cprovided by RGD
Official Full Name
methyltransferase 21C, AARS1 lysineprovided by RGD
Primary source
RGD:1561425
See related
EnsemblRapid:ENSRNOG00000011591 AllianceGenome:RGD:1561425
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1561425
Summary
Predicted to enable heat shock protein binding activity and protein-lysine N-methyltransferase activity. Predicted to be involved in peptidyl-lysine trimethylation. Predicted to act upstream of or within cellular response to hormone stimulus; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; and skeletal muscle tissue development. Predicted to be located in nucleus. Predicted to be part of protein-containing complex. Predicted to be active in cytosol. Orthologous to human METTL21C (methyltransferase 21C, AARS1 lysine). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 138.0) and Heart (RPKM 4.3) See more
Orthologs
human all
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Genomic context

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See Mettl21c in Genome Data Viewer
Location:
9q22
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (53625473..53637220, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (46130451..46145128, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (50750971..50762082, complement)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein L30, pseudogene 7 Neighboring gene U6 spliceosomal RNA Neighboring gene tripeptidyl peptidase 2 Neighboring gene DnaJ heat shock protein family (Hsp40) member C14, pseudogene 2 Neighboring gene coiled-coil domain containing 168

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. METTL21C is a potential pleiotropic gene for osteoporosis and sarcopenia acting through the modulation of the NF-κB signaling pathway. Huang J, et al. J Bone Miner Res, 2014 Jul. PMID 24677265, Free PMC Article
  2. Lysine methylation of VCP by a member of a novel human protein methyltransferase family. Kernstock S, et al. Nat Commun, 2012. PMID 22948820
  3. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. Cloutier P, et al. PLoS Genet, 2013. PMID 23349634, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables heat shock protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein-lysine N-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-lysine N-methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to dexamethasone stimulus ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within hormone-mediated apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in peptidyl-lysine methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in peptidyl-lysine methylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein methylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within skeletal muscle tissue development ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein-lysine methyltransferase METTL21C
Names
methyltransferase like 21C
methyltransferase-like protein 21C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106908.1 → NP_001100378.1  protein-lysine methyltransferase METTL21C

    See identical proteins and their annotated locations for NP_001100378.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473965
    UniProtKB/TrEMBL
    A6INS0, D3ZJG1
    Related
    ENSRNOP00000015490.5, ENSRNOT00000015492.7
    Conserved Domains (1) summary
    cl17173
    Location:57 → 224
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    53625473..53637220 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017596347.3 → XP_017451836.1  protein-lysine methyltransferase METTL21C isoform X1

    UniProtKB/TrEMBL
    A6INS0, D3ZJG1
    Conserved Domains (1) summary
    cl17173
    Location:57 → 224
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  2. XM_039083266.2 → XP_038939194.1  protein-lysine methyltransferase METTL21C isoform X2

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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