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Ercc5 ERCC excision repair 5, endonuclease [ Rattus norvegicus (Norway rat) ]

Gene ID: 301382, updated on 6-Jun-2024

Summary

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Official Symbol
Ercc5provided by RGD
Official Full Name
ERCC excision repair 5, endonucleaseprovided by RGD
Primary source
RGD:1586176
See related
Ensembl:ENSRNOG00000022812 AllianceGenome:RGD:1586176
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Xpg
Summary
Predicted to enable several functions, including DNA binding activity; RNA polymerase II complex binding activity; and protein homodimerization activity. Predicted to be involved in several processes, including DNA repair; negative regulation of apoptotic process; and response to UV-C. Predicted to act upstream of or within UV protection; determination of adult lifespan; and nucleotide-excision repair. Predicted to be part of nucleotide-excision repair complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in cerebrooculofacioskeletal syndrome 3; melanoma; and xeroderma pigmentosum group G. Orthologous to human ERCC5 (ERCC excision repair 5, endonuclease). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 124.3), Heart (RPKM 115.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ercc5 in Genome Data Viewer
Location:
9q22
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (53801471..53846611)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (46309477..46354478)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (50928847..50970962)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene testis expressed 30 Neighboring gene protein O-glucosyltransferase 2 Neighboring gene basic, immunoglobulin-like variable motif containing Neighboring gene methyltransferase like 21C-like 1 Neighboring gene cell division cycle associated 3 like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Association between single nucleotide polymorphisms (SNPs) and toxicity of advanced non-small-cell lung cancer patients treated with chemotherapy. Zhang L, et al. PLoS One, 2012. PMID 23118991, Free PMC Article
  2. UV-induced apoptosis in XPG-deficient fibroblasts involves activation of CD95 and caspases but not p53. Clément V, et al. DNA Repair (Amst), 2007 May 1. PMID 17208056
  3. Suppression of UV-induced apoptosis by the human DNA repair protein XPG. Clément V, et al. Cell Death Differ, 2006 Mar. PMID 16167068
  4. Structural determinants for substrate binding and catalysis by the structure-specific endonuclease XPG. Hohl M, et al. J Biol Chem, 2003 May 23. PMID 12644470
  5. Reduced expression levels of nucleotide excision repair genes in lung cancer: a case-control analysis. Cheng L, et al. Carcinogenesis, 2000 Aug. PMID 10910954

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA endonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA endonuclease activity ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II complex binding ISO
Inferred from Sequence Orthology
more info
  
enables bubble DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables damaged DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables endonuclease activity ISO
Inferred from Sequence Orthology
more info
  
enables enzyme activator activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
enables single-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables single-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA repair ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within UV protection ISO
Inferred from Sequence Orthology
more info
  
involved_in base-excision repair, AP site formation ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within determination of adult lifespan ISO
Inferred from Sequence Orthology
more info
  
involved_in double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within multicellular organism growth ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within nucleotide-excision repair ISO
Inferred from Sequence Orthology
more info
  
involved_in nucleotide-excision repair ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within response to UV ISO
Inferred from Sequence Orthology
more info
  
involved_in response to UV ISO
Inferred from Sequence Orthology
more info
  
involved_in response to UV-C ISO
Inferred from Sequence Orthology
more info
  
involved_in transcription-coupled nucleotide-excision repair ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of DNA replication factor A complex ISO
Inferred from Sequence Orthology
more info
  
part_of nucleotide-excision repair complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
DNA excision repair protein ERCC-5
Names
DNA repair protein complementing XP-G cells
excision repair cross-complementation group 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001426998.1 → NP_001413927.1  DNA excision repair protein ERCC-5

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/TrEMBL
    A0A096MKI6, D3ZTV2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    53801471..53846611
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063266934.1 → XP_063123004.1  DNA excision repair protein ERCC-5 isoform X2

    UniProtKB/TrEMBL
    A0A096MKI6

  2. XM_017596798.3 → XP_017452287.2  DNA excision repair protein ERCC-5 isoform X4

    UniProtKB/TrEMBL
    A6INS6
    Conserved Domains (1) summary
    TIGR00600
    Location:1 → 890
    rad2; DNA excision repair protein (rad2)

  3. XM_017596799.3 → XP_017452288.2  DNA excision repair protein ERCC-5 isoform X4

    UniProtKB/TrEMBL
    A6INS6
    Conserved Domains (1) summary
    TIGR00600
    Location:1 → 890
    rad2; DNA excision repair protein (rad2)

  4. XM_017596800.3 → XP_017452289.2  DNA excision repair protein ERCC-5 isoform X5

    UniProtKB/TrEMBL
    A6INS6
    Conserved Domains (1) summary
    TIGR00600
    Location:1 → 890
    rad2; DNA excision repair protein (rad2)

  5. XM_039084556.2 → XP_038940484.1  DNA excision repair protein ERCC-5 isoform X3

    UniProtKB/TrEMBL
    A6INS6
    Conserved Domains (1) summary
    TIGR00600
    Location:1 → 890
    rad2; DNA excision repair protein (rad2)

  6. XM_063266935.1 → XP_063123005.1  DNA excision repair protein ERCC-5 isoform X6

  7. XM_039084555.2 → XP_038940483.1  DNA excision repair protein ERCC-5 isoform X1

    UniProtKB/TrEMBL
    A0A096MKI6
    Related
    ENSRNOP00000068529.2
    Conserved Domains (1) summary
    TIGR00600
    Location:11 → 1007
    rad2; DNA excision repair protein (rad2)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001106910.1: Suppressed sequence

    Description
    NM_001106910.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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