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Hibch 3-hydroxyisobutyryl-CoA hydrolase [ Rattus norvegicus (Norway rat) ]

Gene ID: 301384, updated on 10-Jul-2024

Summary

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Official Symbol
Hibchprovided by RGD
Official Full Name
3-hydroxyisobutyryl-CoA hydrolaseprovided by RGD
Primary source
RGD:1308392
See related
EnsemblRapid:ENSRNOG00000028557 AllianceGenome:RGD:1308392
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable 3-hydroxyisobutyryl-CoA hydrolase activity. Predicted to be involved in valine catabolic process. Predicted to be active in mitochondrion. Orthologous to human HIBCH (3-hydroxyisobutyryl-CoA hydrolase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 238.2), Liver (RPKM 169.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Hibch in Genome Data Viewer
Location:
9q22
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (56082082..56161796, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (48590097..48669896, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (53446185..53526727, complement)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene similar to human chromosome 2 open reading frame 88 Neighboring gene serine and arginine rich splicing factor 7, pseudogene 4 Neighboring gene inositol polyphosphate-1-phosphatase Neighboring gene post-GPI attachment to proteins 2, pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Purification and partial characterization of 3-hydroxyisobutyryl-coenzyme A hydrolase of rat liver. Shimomura Y, et al. J Biol Chem, 1994 May 13. PMID 8188708
  2. Primary structure and tissue-specific expression of human beta-hydroxyisobutyryl-coenzyme A hydrolase. Hawes JW, et al. J Biol Chem, 1996 Oct 18. PMID 8824301
  3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  4. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 3-hydroxyisobutyryl-CoA hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3-hydroxyisobutyryl-CoA hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables 3-hydroxyisobutyryl-CoA hydrolase activity ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in valine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in valine catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
3-hydroxyisobutyryl-CoA hydrolase, mitochondrial
Names
3-hydroxyisobutyryl-Coenzyme A hydrolase
HIB-CoA hydrolase
HIBYL-CoA-H
NP_001013130.1
NP_001385597.1
XP_038939216.2
XP_038939217.1
XP_063123006.1
XP_063123007.1
XP_063123008.1
XP_063123009.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013112.2 → NP_001013130.1  3-hydroxyisobutyryl-CoA hydrolase, mitochondrial isoform 2

    See identical proteins and their annotated locations for NP_001013130.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/Swiss-Prot
    Q5XIE6
    Related
    ENSRNOP00000046370.2, ENSRNOT00000040650.5
    Conserved Domains (1) summary
    pfam16113
    Location:46 → 296
    ECH_2; Enoyl-CoA hydratase/isomerase

  2. NM_001398668.1 → NP_001385597.1  3-hydroxyisobutyryl-CoA hydrolase, mitochondrial isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/Swiss-Prot
    Q5XIE6
    UniProtKB/TrEMBL
    A0A8I5ZL23, A6INV5
    Related
    ENSRNOP00000032041.4, ENSRNOT00000029677.8
    Conserved Domains (1) summary
    pfam16113
    Location:46 → 374
    ECH_2; Enoyl-CoA hydratase/isomerase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    56082082..56161796 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039083289.2 → XP_038939217.1  3-hydroxyisobutyryl-CoA hydrolase, mitochondrial isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZL23
    Conserved Domains (1) summary
    pfam16113
    Location:19 → 347
    ECH_2; Enoyl-CoA hydratase/isomerase

  2. XM_063266936.1 → XP_063123006.1  3-hydroxyisobutyryl-CoA hydrolase, mitochondrial isoform X3

  3. XM_039083288.2 → XP_038939216.2  3-hydroxyisobutyryl-CoA hydrolase, mitochondrial isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZL23, A0A8I6A0J8
    Related
    ENSRNOP00000084082.2, ENSRNOT00000116077.2

  4. XM_063266938.1 → XP_063123008.1  3-hydroxyisobutyryl-CoA hydrolase, mitochondrial isoform X4

  5. XM_063266937.1 → XP_063123007.1  3-hydroxyisobutyryl-CoA hydrolase, mitochondrial isoform X4

  6. XM_063266939.1 → XP_063123009.1  3-hydroxyisobutyryl-CoA hydrolase, mitochondrial isoform X5

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5XIE6.2 GenPept UniProtKB/Swiss-Prot:Q5XIE6

Gene LinkOut

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