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Fastkd2 FAST kinase domains 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 301463, updated on 10-Jul-2024

Summary

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Official Symbol
Fastkd2provided by RGD
Official Full Name
FAST kinase domains 2provided by RGD
Primary source
RGD:1307883
See related
EnsemblRapid:ENSRNOG00000023923 AllianceGenome:RGD:1307883
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1307883
Summary
Predicted to enable rRNA binding activity. Predicted to be involved in several processes, including mitochondrial gene expression; mitochondrial large ribosomal subunit assembly; and posttranscriptional regulation of gene expression. Predicted to be located in mitochondrial nucleoid. Predicted to be active in mitochondrial matrix and ribonucleoprotein granule. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency. Orthologous to human FASTKD2 (FAST kinase domains 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 85.8), Muscle (RPKM 68.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Fastkd2 in Genome Data Viewer
Location:
9q32
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (72659961..72681986)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (65166148..65188184)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (70448386..70471420)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene dystrotelin Neighboring gene malate dehydrogenase 1B Neighboring gene dnaJ homolog subfamily A member 1 pseudogene Neighboring gene uncharacterized LOC108351943 Neighboring gene uncharacterized LOC134480376

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Mitochondrial RNA Granules Are Centers for Posttranscriptional RNA Processing and Ribosome Biogenesis. Antonicka H, et al. Cell Rep, 2015 Feb 17. PMID 25683715
  2. A Genome-wide CRISPR Death Screen Identifies Genes Essential for Oxidative Phosphorylation. Arroyo JD, et al. Cell Metab, 2016 Dec 13. PMID 27667664, Free PMC Article
  3. Fast kinase domain-containing protein 3 is a mitochondrial protein essential for cellular respiration. Simarro M, et al. Biochem Biophys Res Commun, 2010 Oct 22. PMID 20869947, Free PMC Article
  4. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
  5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC94943

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables rRNA binding IEA
Inferred from Electronic Annotation
more info
  
enables rRNA binding ISO
Inferred from Sequence Orthology
more info
  
enables rRNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in RNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in RNA processing ISO
Inferred from Sequence Orthology
more info
  
involved_in RNA processing ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mitochondrial RNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial large ribosomal subunit assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial large ribosomal subunit assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrial large ribosomal subunit assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mitochondrial translation IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial translation ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrial translation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of mitochondrial translation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of mitochondrial translation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of mitochondrial translation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of mitochondrial mRNA stability IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of mitochondrial mRNA stability IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial nucleoid IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial nucleoid ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial nucleoid ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
is_active_in ribonucleoprotein granule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in ribonucleoprotein granule IEA
Inferred from Electronic Annotation
more info
  
located_in ribonucleoprotein granule ISO
Inferred from Sequence Orthology
more info
  
located_in ribonucleoprotein granule ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
FAST kinase domain-containing protein 2, mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001009673.1 → NP_001009673.1  FAST kinase domain-containing protein 2, mitochondrial isoform 2

    See identical proteins and their annotated locations for NP_001009673.1

    Status: PROVISIONAL

    Source sequence(s)
    BC088416
    UniProtKB/Swiss-Prot
    Q5M7V7
    Conserved Domains (4) summary
    smart00952
    Location:609 → 665
    RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
    pfam06743
    Location:433 → 502
    FAST_1; FAST kinase-like protein, subdomain 1
    pfam08368
    Location:551 → 586
    FAST_2; FAST kinase-like protein, subdomain 2
    pfam08689
    Location:356 → 516
    Med5; Mediator complex subunit Med5

  2. NM_001398523.1 → NP_001385452.1  FAST kinase domain-containing protein 2, mitochondrial isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/TrEMBL
    A0A0H2UHK3, A6IPH0
    Related
    ENSRNOP00000112158.1, ENSRNOT00000159270.1
    Conserved Domains (3) summary
    smart00952
    Location:619 → 675
    RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
    pfam06743
    Location:443 → 512
    FAST_1; FAST kinase-like protein, subdomain 1
    pfam08368
    Location:561 → 596
    FAST_2; FAST kinase-like protein, subdomain 2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    72659961..72681986
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5M7V7.1 GenPept UniProtKB/Swiss-Prot:Q5M7V7

Gene LinkOut

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