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Ikzf2 IKAROS family zinc finger 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 301476, updated on 2-Nov-2024

Summary

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Official Symbol
Ikzf2provided by RGD
Official Full Name
IKAROS family zinc finger 2provided by RGD
Primary source
RGD:1308686
See related
EnsemblRapid:ENSRNOG00000027430 AllianceGenome:RGD:1308686
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Zfpn1a2
Summary
Predicted to enable DNA-binding transcription factor activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Orthologous to human IKZF2 (IKAROS family zinc finger 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 241.3), Muscle (RPKM 48.0) and 7 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ikzf2 in Genome Data Viewer
Location:
9q33
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (78495670..78640896, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (71046038..71191296, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (76621230..76771017, complement)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120094697 Neighboring gene PC-esterase domain containing 1B like 1 Neighboring gene uncharacterized LOC134480292 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene sperm associated antigen 16

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Clinical significance of expanded Foxp3⁺ Helios⁻ regulatory T cells in patients with non-small cell lung cancer. Muto S, et al. Int J Oncol, 2015 Dec. PMID 26460798, Free PMC Article
  2. Helios, a novel dimerization partner of Ikaros expressed in the earliest hematopoietic progenitors. Kelley CM, et al. Curr Biol, 1998 Apr 23. PMID 9560339
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
zinc finger protein Helios
Names
zinc finger protein, subfamily 1A, 2 (Helios)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106916.2 → NP_001100386.2  zinc finger protein Helios

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    Related
    ENSRNOP00000101201.1, ENSRNOT00000160705.1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    78495670..78640896 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006245120.5 → XP_006245182.1  zinc finger protein Helios isoform X4

    See identical proteins and their annotated locations for XP_006245182.1

    UniProtKB/TrEMBL
    A6KFF3
    Conserved Domains (3) summary
    COG5048
    Location:138 → 498
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:114 → 134
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:154 → 179
    zf-H2C2_2; Zinc-finger double domain

  2. XM_063266957.1 → XP_063123027.1  zinc finger protein Helios isoform X3

    UniProtKB/TrEMBL
    A0A8I6AGQ5

  3. XM_063266955.1 → XP_063123025.1  zinc finger protein Helios isoform X1

  4. XM_008767219.4 → XP_008765441.1  zinc finger protein Helios isoform X6

    UniProtKB/TrEMBL
    A6KFF3
    Related
    ENSRNOP00000109346.1, ENSRNOT00000155133.1
    Conserved Domains (4) summary
    COG5048
    Location:122 → 196
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:131 → 151
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:129 → 151
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:143 → 168
    zf-H2C2_2; Zinc-finger double domain

  5. XM_063266959.1 → XP_063123029.1  zinc finger protein Helios isoform X5

  6. XM_063266961.1 → XP_063123031.1  zinc finger protein Helios isoform X7

  7. XM_063266954.1 → XP_063123024.1  zinc finger protein Helios isoform X1

  8. XM_006245119.5 → XP_006245181.1  zinc finger protein Helios isoform X4

    See identical proteins and their annotated locations for XP_006245181.1

    UniProtKB/TrEMBL
    A6KFF3
    Conserved Domains (3) summary
    COG5048
    Location:138 → 498
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:114 → 134
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:154 → 179
    zf-H2C2_2; Zinc-finger double domain

  9. XM_063266956.1 → XP_063123026.1  zinc finger protein Helios isoform X3

    UniProtKB/TrEMBL
    A0A8I6AGQ5
    Related
    ENSRNOP00000111682.1, ENSRNOT00000121577.1

  10. XM_039083325.2 → XP_038939253.1  zinc finger protein Helios isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZMW5, A6KFF3
    Conserved Domains (3) summary
    COG5048
    Location:144 → 504
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:120 → 140
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:160 → 185
    zf-H2C2_2; Zinc-finger double domain

  11. XM_063266958.1 → XP_063123028.1  zinc finger protein Helios isoform X3

    UniProtKB/TrEMBL
    A0A8I6AGQ5

  12. XM_006245121.5 → XP_006245183.1  zinc finger protein Helios isoform X4

    See identical proteins and their annotated locations for XP_006245183.1

    UniProtKB/TrEMBL
    A6KFF3
    Conserved Domains (3) summary
    COG5048
    Location:138 → 498
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:114 → 134
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:154 → 179
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein Strain
Heading Accession and Version

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