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Aamp angio-associated, migratory cell protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 301512, updated on 2-Nov-2024

Summary

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Official Symbol
Aampprovided by RGD
Official Full Name
angio-associated, migratory cell proteinprovided by RGD
Primary source
RGD:1306281
See related
EnsemblRapid:ENSRNOG00000014399 AllianceGenome:RGD:1306281
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable heparin binding activity. Predicted to be involved in smooth muscle cell migration. Predicted to be located in cell surface; intercellular bridge; and microtubule cytoskeleton. Predicted to be active in cytosol. Orthologous to human AAMP (angio associated migratory cell protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 263.4), Testes (RPKM 229.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Aamp in Genome Data Viewer
Location:
9q33
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (83312519..83318325, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (75863382..75869188, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (81560836..81566642, complement)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103690558 Neighboring gene actin related protein 2/3 complex, subunit 2 Neighboring gene G protein-coupled bile acid receptor 1 Neighboring gene transmembrane BAX inhibitor motif containing 1 Neighboring gene PNKD metallo-beta-lactamase domain containing Neighboring gene ciliogenesis associated TTC17 interacting protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Blockade of angio-associated migratory cell protein inhibits smooth muscle cell migration and neointima formation in accelerated atherosclerosis. Vogt F, et al. J Am Coll Cardiol, 2008 Jul 22. PMID 18634987
  2. Angio-associated migratory cell protein is expressed as an extracellular protein by blood-vessel-associated mesenchymal cells. Beckner ME, et al. Microvasc Res, 1999 May. PMID 10329261
  3. Identification of a new immunoglobulin superfamily protein expressed in blood vessels with a heparin-binding consensus sequence. Beckner ME, et al. Cancer Res, 1995 May 15. PMID 7743515
  4. AAMP Regulates Endothelial Cell Migration and Angiogenesis Through RhoA/Rho Kinase Signaling. Hu J, et al. Ann Biomed Eng, 2016 May. PMID 26350504
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. AAMP Regulates Endothelial Cell Migration and Angiogenesis Through RhoA/Rho Kinase Signaling.
    Title: AAMP Regulates Endothelial Cell Migration and Angiogenesis Through RhoA/Rho Kinase Signaling.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables heparin binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in smooth muscle cell migration ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in intercellular bridge IEA
Inferred from Electronic Annotation
more info
  
located_in intercellular bridge ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
angio-associated migratory cell protein
Names
angio-associated migratory protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106920.1 → NP_001100390.1  angio-associated migratory cell protein

    See identical proteins and their annotated locations for NP_001100390.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474004
    UniProtKB/TrEMBL
    A6JVT3, B0K024
    Related
    ENSRNOP00000019497.7, ENSRNOT00000019497.8
    Conserved Domains (3) summary
    smart00320
    Location:390 → 428
    WD40; WD40 repeats
    cd00200
    Location:87 → 387
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:138 → 176
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    83312519..83318325 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006245167.5 → XP_006245229.1  angio-associated migratory cell protein isoform X1

    UniProtKB/TrEMBL
    B0K024
    Conserved Domains (3) summary
    smart00320
    Location:391 → 429
    WD40; WD40 repeats
    cd00200
    Location:88 → 388
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:139 → 177
    7WD40; WD40 repeat [structural motif]

  2. XM_006245169.4 → XP_006245231.1  angio-associated migratory cell protein isoform X3

    UniProtKB/TrEMBL
    B0K024
    Conserved Domains (4) summary
    smart00320
    Location:384 → 422
    WD40; WD40 repeats
    COG2319
    Location:84 → 425
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:81 → 381
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:132 → 170
    7WD40; WD40 repeat [structural motif]

  3. XM_006245168.4 → XP_006245230.1  angio-associated migratory cell protein isoform X2

    UniProtKB/TrEMBL
    B0K024, G3V7V2
    Related
    ENSRNOP00000106938.1, ENSRNOT00000157624.1
    Conserved Domains (4) summary
    smart00320
    Location:385 → 423
    WD40; WD40 repeats
    COG2319
    Location:85 → 426
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:82 → 382
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:133 → 171
    7WD40; WD40 repeat [structural motif]
Nucleotide Protein Strain
Heading Accession and Version

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