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Pof1b POF1B, actin binding protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 302328, updated on 2-Nov-2024

Summary

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Official Symbol
Pof1bprovided by RGD
Official Full Name
POF1B, actin binding proteinprovided by RGD
Primary source
RGD:1560798
See related
EnsemblRapid:ENSRNOG00000004795 AllianceGenome:RGD:1560798
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1560798
Summary
Predicted to enable actin filament binding activity. Predicted to be involved in actin filament organization; bicellular tight junction assembly; and epithelial cell morphogenesis. Predicted to be located in desmosome. Predicted to be active in actin filament; adherens junction; and bicellular tight junction. Human ortholog(s) of this gene implicated in primary ovarian insufficiency 2B. Orthologous to human POF1B (POF1B actin binding protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 59.7), Uterus (RPKM 8.8) and 2 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Pof1b in Genome Data Viewer
Location:
Xq31
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (81875348..81942046, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (77683128..77749827, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (84099618..84167717, complement)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2010106E10 gene like Neighboring gene zinc finger protein 711 Neighboring gene replication factor C subunit 4, pseudogene 1 Neighboring gene uncharacterized LOC134484037 Neighboring gene lactate dehydrogenase A, pseudogene 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The POF1B candidate gene for premature ovarian failure regulates epithelial polarity. Padovano V, et al. J Cell Sci, 2011 Oct 1. PMID 21940798
  2. Disruption of POF1B binding to nonmuscle actin filaments is associated with premature ovarian failure. Lacombe A, et al. Am J Hum Genet, 2006 Jul. PMID 16773570, Free PMC Article
  3. Isolation of mammalian 26S proteasomes and p97/VCP complexes using the ubiquitin-like domain from HHR23B reveals novel proteasome-associated proteins. Besche HC, et al. Biochemistry, 2009 Mar 24. PMID 19182904, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin filament binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin filament organization ISO
Inferred from Sequence Orthology
more info
  
involved_in bicellular tight junction assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in bicellular tight junction assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in epithelial cell morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in epithelial cell morphogenesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in actin filament IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in actin filament ISO
Inferred from Sequence Orthology
more info
  
is_active_in adherens junction IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in adherens junction ISO
Inferred from Sequence Orthology
more info
  
is_active_in bicellular tight junction IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in bicellular tight junction ISO
Inferred from Sequence Orthology
more info
  
located_in desmosome IEA
Inferred from Electronic Annotation
more info
  
located_in desmosome ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein POF1B
Names
premature ovarian failure 1B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106934.1 → NP_001100404.1  protein POF1B

    See identical proteins and their annotated locations for NP_001100404.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473969
    UniProtKB/TrEMBL
    A6IVA4, D3ZWE3
    Related
    ENSRNOP00000006415.5, ENSRNOT00000006415.7
    Conserved Domains (1) summary
    cl24005
    Location:337 → 435
    DUF2570; Protein of unknown function (DUF2570)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    81875348..81942046 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063279892.1 → XP_063135962.1  protein POF1B isoform X2

    UniProtKB/TrEMBL
    A6IVA4, D3ZWE3

  2. XM_039099585.2 → XP_038955513.1  protein POF1B isoform X1

    Conserved Domains (1) summary
    TIGR02169
    Location:273 → 529
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
Nucleotide Protein Strain
Heading Accession and Version

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