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Cul4b cullin 4B [ Rattus norvegicus (Norway rat) ]

Gene ID: 302502, updated on 17-Aug-2024

Summary

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Official Symbol
Cul4bprovided by RGD
Official Full Name
cullin 4Bprovided by RGD
Primary source
RGD:1564494
See related
EnsemblRapid:ENSRNOG00000002585 AllianceGenome:RGD:1564494
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1564494
Summary
Predicted to enable ubiquitin protein ligase binding activity and ubiquitin-protein transferase activity. Predicted to contribute to damaged DNA binding activity. Involved in neuron projection development. Located in cytosol and nucleus. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability Cabezas type. Orthologous to human CUL4B (cullin 4B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 139.8), Thymus (RPKM 133.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
Xq35
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (122154332..122192299, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (117287481..117326688, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (124831391..124870329, complement)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene lysosomal-associated membrane protein 2 Neighboring gene ragulator complex protein LAMTOR5-like Neighboring gene uncharacterized LOC134484034 Neighboring gene MCTS1, re-initiation and release factor Neighboring gene C1GALT1-specific chaperone 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. CUL4B promotes the pathology of adjuvant-induced arthritis in rats through the canonical Wnt signaling. Miao C, et al. J Mol Med (Berl), 2018 Jun. PMID 29626254
  2. MiR-674-5p Suppresses the Proliferation and Migration of Glioma Cells by Targeting Cul4b. Li W, et al. Neurochem Res, 2022 Mar. PMID 34779995
  3. Hepatocyte-specific Smad7 expression attenuates TGF-beta-mediated fibrogenesis and protects against liver damage. Dooley S, et al. Gastroenterology, 2008 Aug. PMID 18602923
  4. X-linked mental retardation gene CUL4B targets ubiquitylation of H3K4 methyltransferase component WDR5 and regulates neuronal gene expression. Nakagawa T, et al. Mol Cell, 2011 Aug 5. PMID 21816345, Free PMC Article
  5. The Cullin 4A/B-DDB1-Cereblon E3 Ubiquitin Ligase Complex Mediates the Degradation of CLC-1 Chloride Channels. Chen YA, et al. Sci Rep, 2015 May 29. PMID 26021757, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Circ_0011058 alleviates RA pathology through the circ_0011058/miR-335-5p/CUL4B signal axis.
    Title: Circ_0011058 alleviates RA pathology through the circ_0011058/miR-335-5p/CUL4B signal axis.
  2. MiR-674-5p Suppresses the Proliferation and Migration of Glioma Cells by Targeting Cul4b.
    Title: MiR-674-5p Suppresses the Proliferation and Migration of Glioma Cells by Targeting Cul4b.
  3. CUL4B expression is up-regulated in synovium and FLS from adjuvant-induced arthritis (AIA) rats. Increased CUL4B promotes the canonical Wnt signaling and promotes the pathogenesis of AIA rats. Decreased miR-101-3p contributes to disordered CUL4B.
    Title: CUL4B promotes the pathology of adjuvant-induced arthritis in rats through the canonical Wnt signaling.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
contributes_to damaged DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in DNA damage response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in UV-damage excision repair ISO
Inferred from Sequence Orthology
more info
  
involved_in astrocyte differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in neuron projection development IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within proteasomal protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein polyubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in ribosome biogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of Cul4-RING E3 ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  
part_of Cul4A-RING E3 ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  
part_of Cul4B-RING E3 ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Cul4B-RING E3 ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cullin-4B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106951.1 → NP_001100421.1  cullin-4B

    See identical proteins and their annotated locations for NP_001100421.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473991
    UniProtKB/TrEMBL
    A0A8I6B5A8, A6JMK5, D3ZK73
    Related
    ENSRNOP00000060639.1, ENSRNOT00000065023.4
    Conserved Domains (3) summary
    smart00182
    Location:654 → 794
    CULLIN; Cullin
    smart00884
    Location:900 → 965
    Cullin_Nedd8; Cullin protein neddylation domain
    pfam00888
    Location:276 → 871
    Cullin; Cullin family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    122154332..122192299 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006257489.5 → XP_006257551.1  cullin-4B isoform X1

    UniProtKB/TrEMBL
    A0A8I6B5A8
    Conserved Domains (3) summary
    smart00182
    Location:592 → 732
    CULLIN; Cullin
    smart00884
    Location:838 → 903
    Cullin_Nedd8; Cullin protein neddylation domain
    pfam00888
    Location:214 → 809
    Cullin; Cullin family

  2. XM_039099624.2 → XP_038955552.1  cullin-4B isoform X2

    UniProtKB/TrEMBL
    A0A8I6B5A8
    Conserved Domains (2) summary
    smart00884
    Location:711 → 776
    Cullin_Nedd8; Cullin protein neddylation domain
    pfam00888
    Location:86 → 683
    Cullin; Cullin family
Nucleotide Protein Strain
Heading Accession and Version

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