Asb11 ankyrin repeat and SOCS box containing 11 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Asb11provided by RGD
Official Full Name: ankyrin repeat and SOCS box containing 11provided by RGD
Primary source: RGD:1566298
See related: EnsemblRapid:ENSRNOG00000003452 AllianceGenome:RGD:1566298
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1566298
Summary: Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in endoplasmic reticulum unfolded protein response; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein K11-linked ubiquitination. Predicted to be located in endoplasmic reticulum. Predicted to be part of Cul5-RING ubiquitin ligase complex. Orthologous to several human genes including ASB9 (ankyrin repeat and SOCS box containing 9). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Muscle (RPKM 215.3) and Heart (RPKM 140.5) See more
Orthologs: human mouse all
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Genomic context

Location:: Xq14

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (33646389..33669790, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (30014485..30037808, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (31758294..31781863, complement)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH130732 (e-PCR)
- UniSTS:214016

RH134847 (e-PCR)
- UniSTS:218125

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ubiquitin-like ligase-substrate adaptor activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin-like ligase-substrate adaptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in endoplasmic reticulum unfolded protein response	IEA Inferred from Electronic Annotation more info
involved_in endoplasmic reticulum unfolded protein response	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in protein K11-linked ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in protein K11-linked ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in protein ubiquitination	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of Cul5-RING ubiquitin ligase complex	IEA Inferred from Electronic Annotation more info
part_of Cul5-RING ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ankyrin repeat and SOCS box protein 11

Names: ankyrin repeat and SOCS box containing 11, E3 ubiquitin protein ligase; ankyrin repeat and SOCS box-containing protein 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106962.2 → NP_001100432.1 ankyrin repeat and SOCS box protein 11 isoform 1

See identical proteins and their annotated locations for NP_001100432.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000021

UniProtKB/TrEMBL

A6K2K4, A6K2K5, D3ZSF1

Related

ENSRNOP00000004693.2, ENSRNOT00000004693.7

Conserved Domains (5) summary

cd00204
Location:37 → 154

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:138 → 229

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:37 → 89

Ank_4; Ankyrin repeats (many copies)

sd00045
Location:37 → 66

ANK; ANK repeat [structural motif]

cl02533
Location:253 → 294

SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
NM_001434014.1 → NP_001420943.1 ankyrin repeat and SOCS box protein 11 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000021
NM_001434015.1 → NP_001420944.1 ankyrin repeat and SOCS box protein 11 isoform 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000021

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086039.1 Reference GRCr8

Range

33646389..33669790 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006256858.5 → XP_006256920.3 ankyrin repeat and SOCS box protein 11 isoform X1

Related

ENSRNOP00000098800.1, ENSRNOT00000131446.1
XM_008773166.3 → XP_008771388.1 ankyrin repeat and SOCS box protein 11 isoform X2

UniProtKB/TrEMBL

A6K2K4

Conserved Domains (5) summary

cd00204
Location:28 → 145

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:129 → 220

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:28 → 80

Ank_4; Ankyrin repeats (many copies)

sd00045
Location:28 → 57

ANK; ANK repeat [structural motif]

cl02533
Location:244 → 285

SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...