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Bcorl1 BCL6 co-repressor-like 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 302810, updated on 2-Nov-2024

Summary

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Official Symbol
Bcorl1provided by RGD
Official Full Name
BCL6 co-repressor-like 1provided by RGD
Primary source
RGD:1566108
See related
EnsemblRapid:ENSRNOG00000005076 AllianceGenome:RGD:1566108
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1566108
Summary
Predicted to enable transcription corepressor activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm and plasma membrane. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Shukla-Vernon syndrome. Orthologous to human BCORL1 (BCL6 corepressor like 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Spleen (RPKM 38.3), Lung (RPKM 30.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Bcorl1 in Genome Data Viewer
Location:
Xq36
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (132394703..132462414)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (127516504..127584529)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (135187468..135233859)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene UTP14A small subunit processome component Neighboring gene U6 spliceosomal RNA Neighboring gene NADH:ubiquinone oxidoreductase subunit B4, pseudogene 3 Neighboring gene E74 like ETS transcription factor 4 Neighboring gene apoptosis inducing factor, mitochondria associated 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. MicroRNA-876-5p inhibits epithelial-mesenchymal transition and metastasis of hepatocellular carcinoma by targeting BCL6 corepressor like 1. Xu Q, et al. Biomed Pharmacother, 2018 Jul. PMID 29679906
  2. [Expression and clinical significance of BCL6 corepressor-like 1 in non-small cell lung cancer]. Zhao X, et al. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, 2015 Dec. PMID 26648304
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
BCL-6 corepressor-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191587.1 → NP_001178516.1  BCL-6 corepressor-like protein 1

    See identical proteins and their annotated locations for NP_001178516.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000021
    UniProtKB/TrEMBL
    F1LYC7
    Related
    ENSRNOP00000006805.6, ENSRNOT00000006805.9
    Conserved Domains (4) summary
    PHA03247
    Location:201 → 636
    PHA03247; large tegument protein UL36; Provisional
    cd14260
    Location:1669 → 1782
    PUFD_like_1; PCGF Ub-like fold discriminator of BCOR-like 1
    sd00045
    Location:1501 → 1532
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:1505 → 1596
    Ank_2; Ankyrin repeats (3 copies)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    132394703..132462414
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039099670.2 → XP_038955598.1  BCL-6 corepressor-like protein 1 isoform X1

    UniProtKB/TrEMBL
    F1LYC7
    Conserved Domains (4) summary
    PHA03247
    Location:201 → 636
    PHA03247; large tegument protein UL36; Provisional
    cd14260
    Location:1669 → 1782
    PUFD_like_1; PCGF Ub-like fold discriminator of BCOR-like 1
    sd00045
    Location:1501 → 1532
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:1505 → 1596
    Ank_2; Ankyrin repeats (3 copies)

  2. XM_039099669.2 → XP_038955597.1  BCL-6 corepressor-like protein 1 isoform X1

    UniProtKB/TrEMBL
    F1LYC7
    Conserved Domains (4) summary
    PHA03247
    Location:201 → 636
    PHA03247; large tegument protein UL36; Provisional
    cd14260
    Location:1669 → 1782
    PUFD_like_1; PCGF Ub-like fold discriminator of BCOR-like 1
    sd00045
    Location:1501 → 1532
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:1505 → 1596
    Ank_2; Ankyrin repeats (3 copies)

  3. XM_039099671.2 → XP_038955599.1  BCL-6 corepressor-like protein 1 isoform X1

    UniProtKB/TrEMBL
    F1LYC7
    Conserved Domains (4) summary
    PHA03247
    Location:201 → 636
    PHA03247; large tegument protein UL36; Provisional
    cd14260
    Location:1669 → 1782
    PUFD_like_1; PCGF Ub-like fold discriminator of BCOR-like 1
    sd00045
    Location:1501 → 1532
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:1505 → 1596
    Ank_2; Ankyrin repeats (3 copies)

  4. XM_039099672.2 → XP_038955600.1  BCL-6 corepressor-like protein 1 isoform X1

    UniProtKB/TrEMBL
    F1LYC7
    Conserved Domains (4) summary
    PHA03247
    Location:201 → 636
    PHA03247; large tegument protein UL36; Provisional
    cd14260
    Location:1669 → 1782
    PUFD_like_1; PCGF Ub-like fold discriminator of BCOR-like 1
    sd00045
    Location:1501 → 1532
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:1505 → 1596
    Ank_2; Ankyrin repeats (3 copies)

  5. XM_039099673.2 → XP_038955601.1  BCL-6 corepressor-like protein 1 isoform X1

    UniProtKB/TrEMBL
    F1LYC7
    Conserved Domains (4) summary
    PHA03247
    Location:201 → 636
    PHA03247; large tegument protein UL36; Provisional
    cd14260
    Location:1669 → 1782
    PUFD_like_1; PCGF Ub-like fold discriminator of BCOR-like 1
    sd00045
    Location:1501 → 1532
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:1505 → 1596
    Ank_2; Ankyrin repeats (3 copies)

  6. XM_039099674.2 → XP_038955602.1  BCL-6 corepressor-like protein 1 isoform X1

    UniProtKB/TrEMBL
    F1LYC7
    Conserved Domains (4) summary
    PHA03247
    Location:201 → 636
    PHA03247; large tegument protein UL36; Provisional
    cd14260
    Location:1669 → 1782
    PUFD_like_1; PCGF Ub-like fold discriminator of BCOR-like 1
    sd00045
    Location:1501 → 1532
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:1505 → 1596
    Ank_2; Ankyrin repeats (3 copies)
Nucleotide Protein Strain
Heading Accession and Version

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