Srl sarcalumenin [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Srlprovided by RGD
Official Full Name: sarcalumeninprovided by RGD
Primary source: RGD:1306564
See related: EnsemblRapid:ENSRNOG00000005269 AllianceGenome:RGD:1306564
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable GTP binding activity. Predicted to be involved in endocytosis and endosomal transport. Predicted to act upstream of or within response to muscle activity involved in regulation of muscle adaptation and store-operated calcium entry. Predicted to be located in membrane. Predicted to be active in cytoplasm; intracellular membrane-bounded organelle; and plasma membrane. Orthologous to human SRL (sarcalumenin). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Muscle (RPKM 2273.6) and Heart (RPKM 1372.4) See more
Orthologs: human mouse all
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Genomic context

Location:: 10q12

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (11540365..11584506)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (11033976..11078103)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (11240135..11284325)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BF396476 (e-PCR)
- UniSTS:245786

SRL__5315 (e-PCR)
- UniSTS:463911

D10Got24 (e-PCR)
- UniSTS:114300

D10Rat51 (e-PCR)
- UniSTS:118192

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within response to muscle activity involved in regulation of muscle adaptation	ISO Inferred from Sequence Orthology more info
involved_in store-operated calcium entry	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within store-operated calcium entry	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: sarcalumenin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001371633.1 → NP_001358562.1 sarcalumenin isoform 1 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

FQ224657, JAXUCZ010000010

UniProtKB/TrEMBL

A0A8I6G9C9, F1LWG8

Related

ENSRNOP00000039064.5, ENSRNOT00000048687.8

Conserved Domains (4) summary

cd09913
Location:526 → 767

EHD; Eps15 homology domain (EHD), C-terminal domain

PRK07764
Location:76 → 309

PRK07764; DNA polymerase III subunits gamma and tau; Validated

TIGR00927
Location:271 → 483

2A1904; K+-dependent Na+/Ca+ exchanger

pfam16880
Location:490 → 521

EHD_N; N-terminal EH-domain containing protein
NM_001371781.1 → NP_001358710.1 sarcalumenin isoform 2 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an exon in the coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.

Source sequence(s)

FQ224657, JAXUCZ010000010

UniProtKB/TrEMBL

A0A8I6A0R8, A6K4S8

Conserved Domains (2) summary

cd09913
Location:95 → 336

EHD; Eps15 homology domain (EHD), C-terminal domain

pfam16880
Location:59 → 90

EHD_N; N-terminal EH-domain containing protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

11540365..11584506

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063268901.1 → XP_063124971.1 sarcalumenin isoform X2

Related

ENSRNOP00000086189.2, ENSRNOT00000111240.2
XM_063268900.1 → XP_063124970.1 sarcalumenin isoform X1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001106979.2: Suppressed sequence

Description

NM_001106979.2: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from mouse, laboratory: Srl (GeneID:106393).