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Adcy9 adenylate cyclase 9 [ Rattus norvegicus (Norway rat) ]

Gene ID: 302950, updated on 10-Jul-2024

Summary

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Symbol
Adcy9provided by RGD
Full Name
adenylate cyclase 9provided by RGD
Primary source
RGD:1304747
See related
EnsemblRapid:ENSRNOG00000049768 AllianceGenome:RGD:1304747
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable adenylate cyclase activity. Involved in cAMP biosynthetic process. Located in axon and dendrite. Orthologous to human ADCY9 (adenylate cyclase 9). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 282.3), Brain (RPKM 141.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Adcy9 in Genome Data Viewer
Location:
10q12
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (11645373..11768462)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (11138966..11262067)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (11392698..11515406)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120095031 Neighboring gene uncharacterized LOC120095032 Neighboring gene uncharacterized LOC102551062 Neighboring gene uncharacterized LOC120095034 Neighboring gene uncharacterized LOC120095035 Neighboring gene CREB binding protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Expression of adenylyl cyclase type IX and calcineurin in synapses of the central nervous system. Sosunov SA, et al. Bull Exp Biol Med, 2001 Feb. PMID 11391406
  2. Upregulated microRNA-210-3p improves sevoflurane-induced protective effect on ventricular remodeling in rats with myocardial infarction by inhibiting ADCY9. Wu Y, et al. Funct Integr Genomics, 2022 Jun. PMID 34988676
  3. Differentially expressed adenylyl cyclase isoforms mediate secretory functions in cholangiocyte subpopulation. Strazzabosco M, et al. Hepatology, 2009 Jul. PMID 19444869, Free PMC Article
  4. Molecular analysis, mutation screening, and association study of adenylate cyclase type 9 gene (ADCY9) in mood disorders. Toyota T, et al. Am J Med Genet, 2002 Jan 8. PMID 11840511
  5. Characterisation of human adenylyl cyclase IX reveals inhibition by Ca(2+)/Calcineurin and differential mRNA plyadenylation. Paterson JM, et al. J Neurochem, 2000 Oct. PMID 10987815

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Upregulated microRNA-210-3p improves sevoflurane-induced protective effect on ventricular remodeling in rats with myocardial infarction by inhibiting ADCY9.
    Title: Upregulated microRNA-210-3p improves sevoflurane-induced protective effect on ventricular remodeling in rats with myocardial infarction by inhibiting ADCY9.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables adenylate cyclase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables adenylate cyclase activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in cAMP biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cAMP biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in cAMP biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within in utero embryonic development ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in axon IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in dendrite IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
adenylate cyclase type 9
NP_001358619.1
XP_008765747.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001371690.1 → NP_001358619.1  adenylate cyclase type 9

    Status: VALIDATED

    Source sequence(s)
    AI058744, JAXUCZ010000010
    UniProtKB/TrEMBL
    A6K4T1
    Conserved Domains (2) summary
    pfam00211
    Location:385 → 573
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam01284
    Location:125 → 237
    MARVEL; Membrane-associating domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    11645373..11768462
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008767525.4 → XP_008765747.1  adenylate cyclase type 9 isoform X1

    See identical proteins and their annotated locations for XP_008765747.1

    UniProtKB/TrEMBL
    A0A096MJB0, M0R5U4
    Related
    ENSRNOP00000064773.3, ENSRNOT00000072802.4
    Conserved Domains (3) summary
    smart00044
    Location:326 → 544
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    pfam00211
    Location:385 → 573
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam10101
    Location:118 → 193
    DUF2339; Predicted membrane protein (DUF2339)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001106980.1: Suppressed sequence

    Description
    NM_001106980.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from chicken: ADCY9 (GeneID:395339).
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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