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Eme2 essential meiotic structure-specific endonuclease subunit 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 302982, updated on 2-Nov-2024

Summary

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Official Symbol
Eme2provided by RGD
Official Full Name
essential meiotic structure-specific endonuclease subunit 2provided by RGD
Primary source
RGD:1304924
See related
EnsemblRapid:ENSRNOG00000024867 AllianceGenome:RGD:1304924
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1304924
Summary
Predicted to enable DNA binding activity. Predicted to contribute to crossover junction DNA endonuclease activity. Predicted to be involved in DNA metabolic process and mitotic intra-S DNA damage checkpoint signaling. Predicted to be located in nucleus. Predicted to be part of Holliday junction resolvase complex. Orthologous to human EME2 (essential meiotic structure-specific endonuclease subunit 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 161.4), Kidney (RPKM 145.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Eme2 in Genome Data Viewer
Location:
10q12
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (14413661..14420489, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (13913216..13915991, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (14253552..14257017, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene transfer RNA proline (anticodon AGG) 67 Neighboring gene hydroxyacyl glutathione hydrolase Neighboring gene insulin-like growth factor binding protein, acid labile subunit Neighboring gene NUBP iron-sulfur cluster assembly factor 2 Neighboring gene splA/ryanodine receptor domain and SOCS box containing 3 Neighboring gene mitochondrial ribosomal protein S34 Neighboring gene NME/NM23 nucleoside diphosphate kinase 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
contributes_to crossover junction DNA endonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in double-strand break repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in double-strand break repair ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic intra-S DNA damage checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in replication fork processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in replication fork processing ISO
Inferred from Sequence Orthology
more info
  
involved_in resolution of meiotic recombination intermediates IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of Holliday junction resolvase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of endodeoxyribonuclease complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
probable crossover junction endonuclease EME2
Names
essential meiotic endonuclease 1 homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001401947.1 → NP_001388876.1  probable crossover junction endonuclease EME2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    D3ZC60
    Related
    ENSRNOP00000029188.6, ENSRNOT00000030458.8

  2. NM_001401948.1 → NP_001388877.1  probable crossover junction endonuclease EME2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    Related
    ENSRNOP00000106725.1, ENSRNOT00000144138.1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    14413661..14420489 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039087091.2 → XP_038943019.1  probable crossover junction endonuclease EME2 isoform X7

    UniProtKB/TrEMBL
    A6HCY3
    Conserved Domains (1) summary
    cl41760
    Location:66 → 260
    XPF_nuclease-like; nuclease domain of XPF/MUS81 family proteins

  2. XM_039087089.2 → XP_038943017.1  probable crossover junction endonuclease EME2 isoform X5

    Conserved Domains (1) summary
    cl41760
    Location:66 → 256
    XPF_nuclease-like; nuclease domain of XPF/MUS81 family proteins

  3. XM_039087083.2 → XP_038943011.1  probable crossover junction endonuclease EME2 isoform X1

    Conserved Domains (1) summary
    cl41760
    Location:66 → 188
    XPF_nuclease-like; nuclease domain of XPF/MUS81 family proteins

  4. XM_017597598.3 → XP_017453087.1  probable crossover junction endonuclease EME2 isoform X2

    UniProtKB/TrEMBL
    B0BNI8
    Conserved Domains (1) summary
    cl41760
    Location:66 → 188
    XPF_nuclease-like; nuclease domain of XPF/MUS81 family proteins

  5. XM_063268922.1 → XP_063124992.1  probable crossover junction endonuclease EME2 isoform X6

  6. XM_039087088.2 → XP_038943016.1  probable crossover junction endonuclease EME2 isoform X4

    Conserved Domains (1) summary
    cl41760
    Location:66 → 256
    XPF_nuclease-like; nuclease domain of XPF/MUS81 family proteins

  7. XM_039087087.2 → XP_038943015.1  probable crossover junction endonuclease EME2 isoform X3

    Conserved Domains (1) summary
    cl41760
    Location:66 → 255
    XPF_nuclease-like; nuclease domain of XPF/MUS81 family proteins

  8. XM_039087084.2 → XP_038943012.1  probable crossover junction endonuclease EME2 isoform X2

    UniProtKB/TrEMBL
    B0BNI8
    Conserved Domains (1) summary
    cl41760
    Location:66 → 188
    XPF_nuclease-like; nuclease domain of XPF/MUS81 family proteins

  9. XM_063268921.1 → XP_063124991.1  probable crossover junction endonuclease EME2 isoform X2

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001129775.1: Suppressed sequence

    Description
    NM_001129775.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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