Telo2 telomere maintenance 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Telo2provided by RGD
Official Full Name: telomere maintenance 2provided by RGD
Primary source: RGD:1305553
See related: EnsemblRapid:ENSRNOG00000016774 AllianceGenome:RGD:1305553
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1305553
Summary: Predicted to enable several functions, including Hsp90 protein binding activity; protein kinase binding activity; and telomeric DNA binding activity. Predicted to be involved in several processes, including positive regulation of TOR signaling; protein stabilization; and telomere maintenance via telomerase. Predicted to be located in cytoplasm; nuclear body; and nuclear periphery. Predicted to be part of ASTRA complex; TORC1 complex; and TORC2 complex. Predicted to be active in cytosol. Orthologous to human TELO2 (telomere maintenance 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Adrenal (RPKM 83.1), Thymus (RPKM 63.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q12

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (14624998..14640235, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (14120491..14135729, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (14461581..14476812, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables Hsp90 protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables Hsp90 protein binding	ISO Inferred from Sequence Orthology more info
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables telomeric DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in 'de novo' cotranslational protein folding	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein stabilization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of TTT Hsp90 cochaperone complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nuclear body	IEA Inferred from Electronic Annotation more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: telomere length regulation protein TEL2 homolog

Names: TEL2, telomere maintenance 2, homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001398652.1 → NP_001385581.1 telomere length regulation protein TEL2 homolog

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/TrEMBL

D3ZQ30

Conserved Domains (1) summary

pfam10193
Location:513 → 621

Telomere_reg-2; Telomere length regulation protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

14624998..14640235 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063268925.1 → XP_063124995.1 telomere length regulation protein TEL2 homolog isoform X2
XM_063268924.1 → XP_063124994.1 telomere length regulation protein TEL2 homolog isoform X1

UniProtKB/TrEMBL

D3ZQ30

Related

ENSRNOP00000022670.4, ENSRNOT00000022670.8
XM_063268926.1 → XP_063124996.1 telomere length regulation protein TEL2 homolog isoform X3
XM_039087100.1 → XP_038943028.1 telomere length regulation protein TEL2 homolog isoform X4
XM_039087101.2 → XP_038943029.1 telomere length regulation protein TEL2 homolog isoform X5