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Unkl unk like zinc finger [ Rattus norvegicus (Norway rat) ]

Gene ID: 302987, updated on 17-Aug-2024

Summary

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Official Symbol
Unklprovided by RGD
Official Full Name
unk like zinc fingerprovided by RGD
Primary source
RGD:1565247
See related
EnsemblRapid:ENSRNOG00000054605 AllianceGenome:RGD:1565247
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1565247
Summary
Predicted to enable metal ion binding activity. Predicted to be located in cytosol. Orthologous to human UNKL (unk like zinc finger). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 53.7), Thymus (RPKM 51.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Unkl in Genome Data Viewer
Location:
10q12
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (14710627..14756725)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (14206125..14252226)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (14547126..14593090)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene small nuclear ribonucleoprotein polypeptide C, pseudogene 3 Neighboring gene uncharacterized LOC120095050 Neighboring gene ubiquinol-cytochrome c reductase complex assembly factor 4 Neighboring gene N-acetylglucosamine-1-phosphate transferase subunit gamma Neighboring gene TSR3 ribosome maturation factor Neighboring gene BAI1-associated protein 3 Neighboring gene microRNA 3547

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Maturation of human dendritic cells is accompanied by functional remodelling of the ubiquitin-proteasome system. Ebstein F, et al. Int J Biochem Cell Biol, 2009 May. PMID 19028597
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
putative E3 ubiquitin-protein ligase UNKL; unk like zinc finger
Names
unkempt family like zinc finger
unkempt family zinc finger-like
unkempt homolog-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001430172.1 → NP_001417101.1  unk like zinc finger isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    D4A3S7

  2. NM_001430173.1 → NP_001417102.1  unk like zinc finger isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    14710627..14756725
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063270091.1 → XP_063126161.1  putative E3 ubiquitin-protein ligase UNKL isoform X9

  2. XM_006246057.4 → XP_006246119.1  putative E3 ubiquitin-protein ligase UNKL isoform X1

    Conserved Domains (3) summary
    pfam00642
    Location:286 → 310
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    pfam13863
    Location:564 → 638
    DUF4200; Domain of unknown function (DUF4200)
    pfam13920
    Location:684 → 721
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

  3. XM_008767609.3 → XP_008765831.1  putative E3 ubiquitin-protein ligase UNKL isoform X4

    Conserved Domains (3) summary
    pfam00642
    Location:286 → 310
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    pfam13863
    Location:488 → 562
    DUF4200; Domain of unknown function (DUF4200)
    pfam13920
    Location:608 → 645
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

  4. XM_017597602.3 → XP_017453091.1  putative E3 ubiquitin-protein ligase UNKL isoform X2

  5. XM_017597603.3 → XP_017453092.1  putative E3 ubiquitin-protein ligase UNKL isoform X3

    Related
    ENSRNOP00000068992.2, ENSRNOT00000092043.3

  6. XM_063270090.1 → XP_063126160.1  putative E3 ubiquitin-protein ligase UNKL isoform X6

    UniProtKB/TrEMBL
    A0A8I6G851

  7. XM_063270088.1 → XP_063126158.1  putative E3 ubiquitin-protein ligase UNKL isoform X5

  8. XM_063270089.1 → XP_063126159.1  putative E3 ubiquitin-protein ligase UNKL isoform X5

  9. XM_008767613.4 → XP_008765835.1  putative E3 ubiquitin-protein ligase UNKL isoform X7

    See identical proteins and their annotated locations for XP_008765835.1

    Conserved Domains (2) summary
    pfam13863
    Location:152 → 226
    DUF4200; Domain of unknown function (DUF4200)
    pfam13920
    Location:272 → 309
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

  10. XM_006246059.5 → XP_006246121.1  putative E3 ubiquitin-protein ligase UNKL isoform X8

    See identical proteins and their annotated locations for XP_006246121.1

    UniProtKB/TrEMBL
    A0A8I6ARA8
    Related
    ENSRNOP00000097110.1, ENSRNOT00000097950.2
    Conserved Domains (2) summary
    pfam13920
    Location:196 → 233
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
    cl03075
    Location:76 → 173
    GrpE; nucleotide exchange factor GrpE
Nucleotide Protein Strain
Heading Accession and Version

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