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Capn15 calpain 15 [ Rattus norvegicus (Norway rat) ]

Gene ID: 303000, updated on 2-Nov-2024

Summary

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Official Symbol
Capn15provided by RGD
Official Full Name
calpain 15provided by RGD
Primary source
RGD:1306514
See related
EnsemblRapid:ENSRNOG00000020239 AllianceGenome:RGD:1306514
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Solh
Summary
Predicted to enable calcium-dependent cysteine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in cytoplasm. Orthologous to human CAPN15 (calpain 15). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 28.2), Thymus (RPKM 26.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Capn15 in Genome Data Viewer
Location:
10q12
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (15477311..15503913, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (14972807..14999411, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (15319772..15346607, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480763 Neighboring gene proline rich 35 Neighboring gene ribosomal protein L36A, pseudogene 7 Neighboring gene uncharacterized LOC120095052 Neighboring gene RAB11 family interacting protein 3 Neighboring gene uncharacterized LOC134480764

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium-dependent cysteine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
calpain-15
Names
small optic lobes homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106990.1 → NP_001100460.1  calpain-15

    See identical proteins and their annotated locations for NP_001100460.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473948
    UniProtKB/TrEMBL
    A6HD81, D3ZJJ4
    Related
    ENSRNOP00000027430.6, ENSRNOT00000027430.8
    Conserved Domains (4) summary
    smart00547
    Location:416 → 440
    ZnF_RBZ; Zinc finger domain
    cd00044
    Location:478 → 793
    CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.
    sd00025
    Location:383 → 398
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    sd00029
    Location:346 → 365
    zf-RanBP2; RanBP2-type Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    15477311..15503913 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063268943.1 → XP_063125013.1  calpain-15 isoform X6

  2. XM_063268939.1 → XP_063125009.1  calpain-15 isoform X2

    UniProtKB/TrEMBL
    A0A0G2KAS0
    Related
    ENSRNOP00000075502.1, ENSRNOT00000088104.3

  3. XM_063268941.1 → XP_063125011.1  calpain-15 isoform X4

  4. XM_063268940.1 → XP_063125010.1  calpain-15 isoform X3

  5. XM_063268938.1 → XP_063125008.1  calpain-15 isoform X1

  6. XM_063268937.1 → XP_063125007.1  calpain-15 isoform X1

  7. XM_063268942.1 → XP_063125012.1  calpain-15 isoform X5

Nucleotide Protein Strain
Heading Accession and Version

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