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Rhbdf1 rhomboid 5 homolog 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 303008, updated on 2-Nov-2024

Summary

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Official Symbol
Rhbdf1provided by RGD
Official Full Name
rhomboid 5 homolog 1provided by RGD
Primary source
RGD:1305075
See related
EnsemblRapid:ENSRNOG00000020594 AllianceGenome:RGD:1305075
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable growth factor binding activity. Predicted to be involved in several processes, including negative regulation of protein secretion; regulation of epidermal growth factor receptor signaling pathway; and regulation of proteasomal protein catabolic process. Predicted to be located in Golgi membrane. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human RHBDF1 (rhomboid 5 homolog 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 43.2), Kidney (RPKM 38.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Rhbdf1 in Genome Data Viewer
Location:
10q12
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (15911282..15924214)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (15406832..15419765)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (15672370..15685285)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene NPR3-like, GATOR1 complex subunit Neighboring gene N-methylpurine-DNA glycosylase Neighboring gene small nuclear ribonucleoprotein U11/U12 subunit 25 Neighboring gene interleukin 9 receptor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Human rhomboid family-1 gene RHBDF1 participates in GPCR-mediated transactivation of EGFR growth signals in head and neck squamous cancer cells. Zou H, et al. FASEB J, 2009 Feb. PMID 18832597, Free PMC Article
  2. Rhomboid family pseudoproteases use the ER quality control machinery to regulate intercellular signaling. Zettl M, et al. Cell, 2011 Apr 1. PMID 21439629, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC124815

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables growth factor binding IEA
Inferred from Electronic Annotation
more info
  
NOT enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
NOT enables serine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in cell migration ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in cell population proliferation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of protein secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of protein secretion ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of epidermal growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of epidermal growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of epidermal growth factor receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of proteasomal protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of proteasomal protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of protein secretion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of protein secretion ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
inactive rhomboid protein 1
Names
iRhom1
rhomboid family 1
rhomboid family member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001030034.2 → NP_001025205.1  inactive rhomboid protein 1

    See identical proteins and their annotated locations for NP_001025205.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/Swiss-Prot
    Q499S9
    UniProtKB/TrEMBL
    A6HDB3
    Related
    ENSRNOP00000027965.3, ENSRNOT00000027965.6
    Conserved Domains (2) summary
    pfam01694
    Location:648 → 789
    Rhomboid; Rhomboid family
    pfam12595
    Location:91 → 308
    Rhomboid_SP; Rhomboid serine protease

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    15911282..15924214
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039085877.2 → XP_038941805.1  inactive rhomboid protein 1 isoform X1

    Conserved Domains (2) summary
    pfam01694
    Location:699 → 840
    Rhomboid; Rhomboid family
    pfam12595
    Location:142 → 359
    Rhomboid_SP; Rhomboid serine protease

  2. XM_039085881.2 → XP_038941809.1  inactive rhomboid protein 1 isoform X2

    Related
    ENSRNOP00000112746.1, ENSRNOT00000145512.1
    Conserved Domains (2) summary
    pfam01694
    Location:683 → 824
    Rhomboid; Rhomboid family
    pfam12595
    Location:126 → 343
    Rhomboid_SP; Rhomboid serine protease

  3. XM_039085878.2 → XP_038941806.1  inactive rhomboid protein 1 isoform X1

    Conserved Domains (2) summary
    pfam01694
    Location:699 → 840
    Rhomboid; Rhomboid family
    pfam12595
    Location:142 → 359
    Rhomboid_SP; Rhomboid serine protease

  4. XM_063268948.1 → XP_063125018.1  inactive rhomboid protein 1 isoform X3

    UniProtKB/Swiss-Prot
    Q499S9
    UniProtKB/TrEMBL
    A6HDB3

  5. XM_039085879.2 → XP_038941807.1  inactive rhomboid protein 1 isoform X1

    Conserved Domains (2) summary
    pfam01694
    Location:699 → 840
    Rhomboid; Rhomboid family
    pfam12595
    Location:142 → 359
    Rhomboid_SP; Rhomboid serine protease

  6. XM_063268949.1 → XP_063125019.1  inactive rhomboid protein 1 isoform X3

    UniProtKB/Swiss-Prot
    Q499S9
    UniProtKB/TrEMBL
    A6HDB3

  7. XM_039085880.2 → XP_038941808.1  inactive rhomboid protein 1 isoform X1

    Conserved Domains (2) summary
    pfam01694
    Location:699 → 840
    Rhomboid; Rhomboid family
    pfam12595
    Location:142 → 359
    Rhomboid_SP; Rhomboid serine protease

  8. XM_063268951.1 → XP_063125021.1  inactive rhomboid protein 1 isoform X3

    UniProtKB/Swiss-Prot
    Q499S9
    UniProtKB/TrEMBL
    A6HDB3

  9. XM_063268950.1 → XP_063125020.1  inactive rhomboid protein 1 isoform X3

    UniProtKB/Swiss-Prot
    Q499S9
    UniProtKB/TrEMBL
    A6HDB3
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q499S9.1 GenPept UniProtKB/Swiss-Prot:Q499S9

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