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Sh3pxd2b SH3 and PX domains 2B [ Rattus norvegicus (Norway rat) ]

Gene ID: 303021, updated on 2-Nov-2024

Summary

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Official Symbol
Sh3pxd2bprovided by RGD
Official Full Name
SH3 and PX domains 2Bprovided by RGD
Primary source
RGD:1309926
See related
EnsemblRapid:ENSRNOG00000004063 AllianceGenome:RGD:1309926
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1309926
Summary
Predicted to enable SH2 domain binding activity and phosphatidylinositol phosphate binding activity. Predicted to be involved in several processes, including osteoblast fate commitment; podosome assembly; and skeletal system development. Predicted to be located in cytoplasm and podosome. Human ortholog(s) of this gene implicated in Frank-Ter Haar syndrome. Orthologous to human SH3PXD2B (SH3 and PX domains 2B). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 65.7), Uterus (RPKM 48.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Sh3pxd2b in Genome Data Viewer
Location:
10q12
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (17422906..17538977)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (16918611..17027499)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (17209152..17296449)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102555877 Neighboring gene transmembrane protein 134, pseudogene 1 Neighboring gene uncharacterized LOC120095060 Neighboring gene ubiquitin domain containing 2 Neighboring gene EF-hand calcium binding domain 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The scaffold protein Tks4 is required for the differentiation of mesenchymal stromal cells (MSCs) into adipogenic and osteogenic lineages. Dülk M, et al. Sci Rep, 2016 Oct 6. PMID 27711054, Free PMC Article
  2. Disruption of the podosome adaptor protein TKS4 (SH3PXD2B) causes the skeletal dysplasia, eye, and cardiac abnormalities of Frank-Ter Haar Syndrome. Iqbal Z, et al. Am J Hum Genet, 2010 Feb 12. PMID 20137777, Free PMC Article
  3. The novel adaptor protein Tks4 (SH3PXD2B) is required for functional podosome formation. Buschman MD, et al. Mol Biol Cell, 2009 Mar. PMID 19144821, Free PMC Article
  4. A novel gene, fad49, plays a crucial role in the immediate early stage of adipocyte differentiation via involvement in mitotic clonal expansion. Hishida T, et al. FEBS J, 2008 Nov. PMID 18959745
  5. The podosomal-adaptor protein SH3PXD2B is essential for normal postnatal development. Mao M, et al. Mamm Genome, 2009 Aug. PMID 19669234, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables SH2 domain binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-3,5-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-3-phosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-4-phosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-5-phosphate binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in adipose tissue development ISO
Inferred from Sequence Orthology
more info
  
involved_in bone development ISO
Inferred from Sequence Orthology
more info
  
involved_in cranial skeletal system development ISO
Inferred from Sequence Orthology
more info
  
involved_in extracellular matrix disassembly ISO
Inferred from Sequence Orthology
more info
  
involved_in eye development ISO
Inferred from Sequence Orthology
more info
  
involved_in heart development ISO
Inferred from Sequence Orthology
more info
  
involved_in osteoblast fate commitment ISO
Inferred from Sequence Orthology
more info
  
involved_in podosome assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of adipose tissue development ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of fat cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of multicellular organism growth ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of stress fiber assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of brood size ISO
Inferred from Sequence Orthology
more info
  
involved_in skeletal system development ISO
Inferred from Sequence Orthology
more info
  
involved_in skeletal system morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in superoxide metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in podosome ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
SH3 and PX domain-containing protein 2B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001398763.1 → NP_001385692.1  SH3 and PX domain-containing protein 2B

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    Related
    ENSRNOP00000005478.7, ENSRNOT00000005478.7
    Conserved Domains (6) summary
    cd06888
    Location:7 → 125
    PX_FISH; The phosphoinositide binding Phox Homology domain of Five SH protein
    cd12018
    Location:850 → 905
    SH3_Tks4_4; Fourth (C-terminal) Src homology 3 domain of Tyrosine kinase substrate with four SH3 domains
    cd12075
    Location:155 → 209
    SH3_Tks4_1; First Src homology 3 domain of Tyrosine kinase substrate with four SH3 domains
    cd12076
    Location:224 → 277
    SH3_Tks4_2; Second Src homology 3 domain of Tyrosine kinase substrate with four SH3 domains
    cd12078
    Location:372 → 424
    SH3_Tks4_3; Third Src homology 3 domain of Tyrosine kinase substrate with four SH3 domains
    PHA03307
    Location:433 → 802
    PHA03307; transcriptional regulator ICP4; Provisional

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    17422906..17538977
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039087129.2 → XP_038943057.1  SH3 and PX domain-containing protein 2B isoform X2

    Conserved Domains (3) summary
    cd06888
    Location:7 → 125
    PX_FISH; The phosphoinositide binding Phox Homology domain of Five SH protein
    cd12075
    Location:155 → 209
    SH3_Tks4_1; First Src homology 3 domain of Tyrosine kinase substrate with four SH3 domains
    cl17036
    Location:252 → 305
    SH3; Src Homology 3 domain superfamily

  2. XM_039087130.2 → XP_038943058.1  SH3 and PX domain-containing protein 2B isoform X4

    Conserved Domains (4) summary
    cd06888
    Location:7 → 125
    PX_FISH; The phosphoinositide binding Phox Homology domain of Five SH protein
    cd12075
    Location:155 → 209
    SH3_Tks4_1; First Src homology 3 domain of Tyrosine kinase substrate with four SH3 domains
    cd12076
    Location:252 → 305
    SH3_Tks4_2; Second Src homology 3 domain of Tyrosine kinase substrate with four SH3 domains
    cl17036
    Location:400 → 425
    SH3; Src Homology 3 domain superfamily

  3. XM_063268956.1 → XP_063125026.1  SH3 and PX domain-containing protein 2B isoform X3

  4. XM_017597616.3 → XP_017453105.1  SH3 and PX domain-containing protein 2B isoform X1

    UniProtKB/TrEMBL
    A0A8I6GKH6, M0RCP2
    Related
    ENSRNOP00000067367.2, ENSRNOT00000073675.5

  5. XM_063268957.1 → XP_063125027.1  SH3 and PX domain-containing protein 2B isoform X5

Nucleotide Protein Strain
Heading Accession and Version

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