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N4bp3 Nedd4 binding protein 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 303112, updated on 5-Mar-2024

Summary

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Symbol
N4bp3provided by RGD
Full Name
Nedd4 binding protein 3provided by RGD
Primary source
RGD:1308356
See related
Ensembl:ENSRNOG00000021731 AllianceGenome:RGD:1308356
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1308356; C330016o10rik
Summary
Predicted to be involved in nervous system development. Predicted to be located in axon and dendrite. Predicted to be active in cytoplasmic vesicle. Orthologous to human N4BP3 (NEDD4 binding protein 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 54.1), Testes (RPKM 36.1) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See N4bp3 in Genome Data Viewer
Location:
10q22
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (36400053..36407609, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (35898031..35906704, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (34996702..35005365, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene NHP2 ribonucleoprotein Neighboring gene required for meiotic nuclear division 5 homolog B Neighboring gene uncharacterized LOC102553843 Neighboring gene uncharacterized LOC120095096 Neighboring gene trafficking protein particle complex 2B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The Nedd4-binding protein 3 (N4BP3) is crucial for axonal and dendritic branching in developing neurons. Schmeisser MJ, et al. Neural Dev, 2013 Sep 17. PMID 24044555, Free PMC Article
  2. Identification of developmentally expressed proteins that functionally interact with Nedd4 ubiquitin ligase. Murillas R, et al. J Biol Chem, 2002 Jan 25. PMID 11717310
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
acts_upstream_of_positive_effect innate immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in nervous system development IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in axon IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasmic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in dendrite IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
nedd4 binding protein 3
Names
NEDD4-binding protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033893.1 → NP_001029065.1  nedd4 binding protein 3

    See identical proteins and their annotated locations for NP_001029065.1

    Status: PROVISIONAL

    Source sequence(s)
    DQ176639
    UniProtKB/Swiss-Prot
    Q3LUD3
    UniProtKB/TrEMBL
    A6HE69
    Conserved Domains (2) summary
    COG1429
    Location:226 → 379
    CobN; Cobalamin biosynthesis protein CobN, Mg-chelatase [Coenzyme transport and metabolism]
    pfam06818
    Location:361 → 519
    Fez1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    36400053..36407609 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008767681.4 → XP_008765903.1  nedd4 binding protein 3 isoform X1

    See identical proteins and their annotated locations for XP_008765903.1

    UniProtKB/Swiss-Prot
    Q3LUD3
    UniProtKB/TrEMBL
    A6HE69
    Related
    ENSRNOP00000030035.2
    Conserved Domains (2) summary
    COG1429
    Location:226 → 379
    CobN; Cobalamin biosynthesis protein CobN, Mg-chelatase [Coenzyme transport and metabolism]
    pfam06818
    Location:361 → 519
    Fez1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3LUD3.1 GenPept UniProtKB/Swiss-Prot:Q3LUD3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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