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Fstl4 follistatin-like 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 303130, updated on 2-Nov-2024

Summary

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Official Symbol
Fstl4provided by RGD
Official Full Name
follistatin-like 4provided by RGD
Primary source
RGD:1307227
See related
EnsemblRapid:ENSRNOG00000006565 AllianceGenome:RGD:1307227
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable brain-derived neurotrophic factor binding activity. Predicted to be involved in cell differentiation and regulation of BMP signaling pathway. Predicted to act upstream of or within negative regulation of brain-derived neurotrophic factor receptor signaling pathway; negative regulation of collateral sprouting; and negative regulation of dendritic spine development. Predicted to be located in secretory granule. Predicted to be active in extracellular region. Orthologous to human FSTL4 (follistatin like 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 21.4), Testes (RPKM 6.3) and 3 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Fstl4 in Genome Data Viewer
Location:
10q22
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (37412288..37845405)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (36911422..37344545)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (38104344..38532216)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102548961 Neighboring gene uncharacterized LOC120095321 Neighboring gene uncharacterized LOC134480790 Neighboring gene uncharacterized LOC108352083 Neighboring gene 60S ribosomal protein L14 pseudogene Neighboring gene heat shock protein family A (Hsp70) member 4 Neighboring gene ribosomal protein S2, pseudogene 16

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. SPIG1 negatively regulates BDNF maturation. Suzuki R, et al. J Neurosci, 2014 Feb 26. PMID 24573299, Free PMC Article
  2. Phosphorylation and degradation of tomosyn-2 de-represses insulin secretion. Bhatnagar S, et al. J Biol Chem, 2014 Sep 5. PMID 25002582, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables brain-derived neurotrophic factor binding ISO
Inferred from Sequence Orthology
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
NOT acts_upstream_of_or_within negative regulation of axon extension ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of brain-derived neurotrophic factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of collateral sprouting ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of dendritic spine development ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of BMP signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of collateral sprouting ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in secretory granule ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
follistatin-related protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107000.4 → NP_001100470.1  follistatin-related protein 4 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001100470.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A6HEB5, D3ZJ81
    Related
    ENSRNOP00000060019.1, ENSRNOT00000067809.3
    Conserved Domains (7) summary
    cd05736
    Location:357 → 432
    Ig2_Follistatin_like; Second immunoglobulin (Ig)-like domain of a follistatin-like molecule encoded by the Mahya gene and similar proteins
    smart00410
    Location:255 → 336
    IG_like; Immunoglobulin like
    cd00104
    Location:92 → 132
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    pfam07679
    Location:340 → 429
    I-set; Immunoglobulin I-set domain
    pfam13499
    Location:178 → 241
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:178 → 242
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cl11960
    Location:266 → 322
    Ig; Immunoglobulin domain

  2. NM_001414342.2 → NP_001401271.1  follistatin-related protein 4 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A0A8I5ZYD0
    Related
    ENSRNOP00000084074.1, ENSRNOT00000116801.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    37412288..37845405
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039085928.2 → XP_038941856.1  follistatin-related protein 4 isoform X3

    Conserved Domains (1) summary
    cd05736
    Location:26 → 118
    IgI_2_Follistatin_like; Second immunoglobulin (Ig)-like domain of a Follistatin-related protein 5, and similar domains; member of the I-set of Ig superfamily (IgSF) domains

  2. XM_039085927.2 → XP_038941855.1  follistatin-related protein 4 isoform X3

    Conserved Domains (1) summary
    cd05736
    Location:26 → 118
    IgI_2_Follistatin_like; Second immunoglobulin (Ig)-like domain of a Follistatin-related protein 5, and similar domains; member of the I-set of Ig superfamily (IgSF) domains

  3. XM_063268974.1 → XP_063125044.1  follistatin-related protein 4 isoform X2

  4. XM_039085925.2 → XP_038941853.1  follistatin-related protein 4 isoform X1

    Conserved Domains (1) summary
    cd05736
    Location:57 → 149
    IgI_2_Follistatin_like; Second immunoglobulin (Ig)-like domain of a Follistatin-related protein 5, and similar domains; member of the I-set of Ig superfamily (IgSF) domains
Nucleotide Protein Strain
Heading Accession and Version

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