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Neurl4 neuralized E3 ubiquitin protein ligase 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 303248, updated on 2-Nov-2024

Summary

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Official Symbol
Neurl4provided by RGD
Official Full Name
neuralized E3 ubiquitin protein ligase 4provided by RGD
Primary source
RGD:1308056
See related
EnsemblRapid:ENSRNOG00000016109 AllianceGenome:RGD:1308056
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Gps2l
Summary
Predicted to enable ubiquitin protein ligase activity. Predicted to act upstream of or within mitochondrial DNA repair and spermatogenesis. Predicted to be located in mitochondrion. Orthologous to human NEURL4 (neuralized E3 ubiquitin protein ligase 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 118.8), Brain (RPKM 84.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Neurl4 in Genome Data Viewer
Location:
10q24
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (55123471..55135971)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (54624923..54637262)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (56511861..56524233)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 Neighboring gene protein phosphatase 1, regulatory (inhibitor) subunit 2 like 1 Neighboring gene G protein pathway suppressor 2 Neighboring gene eukaryotic translation initiation factor 5A Neighboring gene Y box binding protein 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within mitochondrial DNA repair ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within spermatogenesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
neuralized-like protein 4
Names
neuralized homolog 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107013.2 → NP_001100483.1  neuralized-like protein 4 isoform 2

    See identical proteins and their annotated locations for NP_001100483.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A0A8I6GKM4, A6HFW0
    Conserved Domains (2) summary
    smart00588
    Location:318 → 439
    NEUZ; domain in neuralized proteins
    cd12887
    Location:720 → 882
    SPRY_NHR_like; SPRY domain in neuralized homology repeat

  2. NM_001414351.1 → NP_001401280.1  neuralized-like protein 4 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    D4A198
    Related
    ENSRNOP00000021883.6, ENSRNOT00000021883.8

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    55123471..55135971
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063269034.1 → XP_063125104.1  neuralized-like protein 4 isoform X3

  2. XM_039085986.2 → XP_038941914.1  neuralized-like protein 4 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A9C7, A0A8I6GKM4
    Related
    ENSRNOP00000088223.1, ENSRNOT00000106054.2
    Conserved Domains (1) summary
    cd12887
    Location:503 → 664
    SPRY_NHR_like; SPRY domain in neuralized homology repeat

  3. XM_039085987.2 → XP_038941915.1  neuralized-like protein 4 isoform X2

    UniProtKB/TrEMBL
    A0A8I6GKM4
    Conserved Domains (1) summary
    cd12887
    Location:698 → 860
    SPRY_NHR_like; SPRY domain in neuralized homology repeat

  4. XM_039085988.2 → XP_038941916.1  neuralized-like protein 4 isoform X4

    Conserved Domains (1) summary
    cd12887
    Location:16 → 180
    SPRY_NHR_like; SPRY domain in neuralized homology repeat

RNA

  1. XR_005489824.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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