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Ybx2 Y box binding protein 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 303250, updated on 17-Aug-2024

Summary

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Official Symbol
Ybx2provided by RGD
Official Full Name
Y box binding protein 2provided by RGD
Primary source
RGD:1305068
See related
EnsemblRapid:ENSRNOG00000017117 AllianceGenome:RGD:1305068
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1305068
Summary
Predicted to enable several functions, including chromatin binding activity; mRNA 3'-UTR binding activity; and ribonucleoprotein complex binding activity. Involved in oocyte development. Located in cytoplasm. Orthologous to human YBX2 (Y-box binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 1092.8) and Thymus (RPKM 46.1) See more
Orthologs
human mouse all
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Genomic context

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Location:
10q24
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (55158420..55164077)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (54659719..54665371)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (56546689..56552339)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene neuralized E3 ubiquitin protein ligase 4 Neighboring gene G protein pathway suppressor 2 Neighboring gene eukaryotic translation initiation factor 5A Neighboring gene solute carrier family 2 member 4 Neighboring gene cofilin-1-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. In the absence of the mouse DNA/RNA-binding protein MSY2, messenger RNA instability leads to spermatogenic arrest. Yang J, et al. Biol Reprod, 2007 Jan. PMID 17035640
  2. Loss of synaptonemal complex protein-1, a synaptonemal complex protein, contributes to the initiation of follicular assembly in the developing rat ovary. Paredes A, et al. Endocrinology, 2005 Dec. PMID 16150897
  3. Absence of the DNA-/RNA-binding protein MSY2 results in male and female infertility. Yang J, et al. Proc Natl Acad Sci U S A, 2005 Apr 19. PMID 15824319, Free PMC Article
  4. Requirement for RNA-binding activity of MSY2 for cytoplasmic localization and retention in mouse oocytes. Yu J, et al. Dev Biol, 2003 Mar 15. PMID 12648488
  5. RNA-binding properties and translation repression in vitro by germ cell-specific MSY2 protein. Yu J, et al. Biol Reprod, 2002 Oct. PMID 12297523

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
  
enables lipid binding ISO
Inferred from Sequence Orthology
more info
  
enables mRNA 3'-UTR binding ISO
Inferred from Sequence Orthology
more info
  
enables mRNA binding ISO
Inferred from Sequence Orthology
more info
  
enables nucleic acid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ribonucleoprotein complex binding ISO
Inferred from Sequence Orthology
more info
  
enables translation regulator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within mRNA stabilization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of translation ISO
Inferred from Sequence Orthology
more info
  
involved_in oocyte development IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within oogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cold-induced thermogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within spermatid development ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
Y-box-binding protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001305212.2 → NP_001292141.1  Y-box-binding protein 2

    Status: VALIDATED

    Source sequence(s)
    CK597131, JAXUCZ010000010
    UniProtKB/TrEMBL
    D4A3P0
    Related
    ENSRNOP00000023003.3, ENSRNOT00000023003.8
    Conserved Domains (1) summary
    pfam00313
    Location:95 → 164
    CSD; 'Cold-shock' DNA-binding domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    55158420..55164077
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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