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Sgsm2 small G protein signaling modulator 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 303304, updated on 18-Sep-2024

Summary

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Official Symbol
Sgsm2provided by RGD
Official Full Name
small G protein signaling modulator 2provided by RGD
Primary source
RGD:1306957
See related
EnsemblRapid:ENSRNOG00000027194 AllianceGenome:RGD:1306957
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Rutbc1
Summary
Predicted to enable GTPase activator activity and small GTPase binding activity. Predicted to be involved in activation of GTPase activity; intracellular protein transport; and late endosome to Golgi transport. Predicted to be located in melanosome. Orthologous to human SGSM2 (small G protein signaling modulator 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 85.8), Adrenal (RPKM 84.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Sgsm2 in Genome Data Viewer
Location:
10q24
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (60216556..60258199, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (59718180..59759822, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (61703837..61745110, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene methyltransferase 16, RNA N6-adenosine Neighboring gene MAX network transcriptional repressor Neighboring gene small nucleolar RNA SNORD91 family Neighboring gene small nucleolar RNA SNORD91 family Neighboring gene TSR1, ribosome maturation factor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity ISO
Inferred from Sequence Orthology
more info
  
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in late endosome to Golgi transport ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of GTPase activity ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in melanosome ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
small G protein signaling modulator 2
Names
RUN and TBC1 domain containing 1
NP_001100490.1
XP_006246802.1
XP_006246803.1
XP_038941941.1
XP_063125131.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107020.1 → NP_001100490.1  small G protein signaling modulator 2

    See identical proteins and their annotated locations for NP_001100490.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473948
    UniProtKB/TrEMBL
    A0A0G2K6Y4, A6HGN6, D3ZW66
    Related
    ENSRNOP00000032080.4, ENSRNOT00000034298.8
    Conserved Domains (3) summary
    smart00164
    Location:793 → 961
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    cd15784
    Location:256 → 424
    PH_RUTBC; Rab-binding Pleckstrin homology domain (PH) of small G-protein signaling modulator 1 and similar proteins
    pfam02759
    Location:42 → 189
    RUN; RUN domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    60216556..60258199 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039086013.2 → XP_038941941.1  small G protein signaling modulator 2 isoform X2

    UniProtKB/TrEMBL
    A0A0G2K6Y4
    Conserved Domains (3) summary
    smart00164
    Location:815 → 983
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    cd15784
    Location:233 → 401
    PH_RUTBC; Rab-binding Pleckstrin homology domain (PH) of small G-protein signaling modulator 1 and similar proteins
    pfam02759
    Location:19 → 162
    RUN; RUN domain

  2. XM_006246740.4 → XP_006246802.1  small G protein signaling modulator 2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K6Y4, A0A0U1RS33
    Related
    ENSRNOP00000075916.1, ENSRNOT00000092314.3
    Conserved Domains (3) summary
    smart00164
    Location:838 → 1006
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    cd15784
    Location:256 → 424
    PH_RUTBC; Rab-binding Pleckstrin homology domain (PH) of small G-protein signaling modulator 1 and similar proteins
    pfam02759
    Location:42 → 189
    RUN; RUN domain

  3. XM_006246741.5 → XP_006246803.1  small G protein signaling modulator 2 isoform X3

    UniProtKB/TrEMBL
    A0A0G2K6Y4
    Conserved Domains (3) summary
    smart00164
    Location:771 → 939
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    cd15784
    Location:189 → 357
    PH_RUTBC; Rab-binding Pleckstrin homology domain (PH) of small G-protein signaling modulator 1 and similar proteins
    pfam02759
    Location:1 → 122
    RUN; RUN domain

  4. XM_063269061.1 → XP_063125131.1  small G protein signaling modulator 2 isoform X4

Nucleotide Protein Strain
Heading Accession and Version

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