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Rab11fip4 RAB11 family interacting protein 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 303337, updated on 2-Nov-2024

Summary

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Official Symbol
Rab11fip4provided by RGD
Official Full Name
RAB11 family interacting protein 4provided by RGD
Primary source
RGD:1305063
See related
EnsemblRapid:ENSRNOG00000014135 AllianceGenome:RGD:1305063
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1305063
Summary
Predicted to enable protein homodimerization activity and small GTPase binding activity. Predicted to be involved in endocytic recycling and regulation of cytokinesis. Predicted to be located in endosome. Predicted to be active in cleavage furrow; cytoplasmic vesicle; and midbody. Orthologous to human RAB11FIP4 (RAB11 family interacting protein 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 213.6), Kidney (RPKM 78.6) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Rab11fip4 in Genome Data Viewer
Location:
10q25
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (65048070..65156086)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (64550109..64658123)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (66942363..67051672)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene FAU ubiquitin like and ribosomal protein S30 fusion like 2 Neighboring gene neurofibromin 1 Neighboring gene ecotropic viral integration site 2B Neighboring gene U6 spliceosomal RNA Neighboring gene ecotropic viral integration site 2A Neighboring gene uncharacterized LOC134480704 Neighboring gene U6 spliceosomal RNA Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC102550168 Neighboring gene transfer RNA threonine (anticodon CGU) 1 Neighboring gene microRNA 193a Neighboring gene microRNA 193

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Mouse Rab11-FIP4 regulates proliferation and differentiation of retinal progenitors in a Rab11-independent manner. Muto A, et al. Dev Dyn, 2007 Jan. PMID 17089410
  2. Rab11-FIP4 interacts with Rab11 in a GTP-dependent manner and its overexpression condenses the Rab11 positive compartment in HeLa cells. Wallace DM, et al. Biochem Biophys Res Commun, 2002 Dec 20. PMID 12470645
  3. The FIP3-Rab11 protein complex regulates recycling endosome targeting to the cleavage furrow during late cytokinesis. Wilson GM, et al. Mol Biol Cell, 2005 Feb. PMID 15601896, Free PMC Article
  4. Rab11-FIP3 and FIP4 interact with Arf6 and the exocyst to control membrane traffic in cytokinesis. Fielding AB, et al. EMBO J, 2005 Oct 5. PMID 16148947, Free PMC Article
  5. A protein interaction network for Ecm29 links the 26 S proteasome to molecular motors and endosomal components. Gorbea C, et al. J Biol Chem, 2010 Oct 8. PMID 20682791, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in endocytic recycling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neural retina development IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of G1 to G0 transition IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cytokinesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cleavage furrow IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cleavage furrow ISO
Inferred from Sequence Orthology
more info
  
is_active_in endocytic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endocytic vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in endosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in midbody IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in midbody ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in recycling endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in recycling endosome membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
rab11 family-interacting protein 4
Names
RAB11 family interacting protein 4 (class II)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107023.1 → NP_001100493.1  rab11 family-interacting protein 4

    See identical proteins and their annotated locations for NP_001100493.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473948
    UniProtKB/TrEMBL
    A6HH90, D3ZHE5
    Related
    ENSRNOP00000018988.3, ENSRNOT00000018986.6
    Conserved Domains (3) summary
    pfam09457
    Location:596 → 636
    RBD-FIP; FIP domain
    pfam13499
    Location:21 → 78
    EF-hand_7; EF-hand domain pair
    cl03075
    Location:428 → 512
    GrpE; nucleotide exchange factor GrpE

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    65048070..65156086
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006246903.5 → XP_006246965.1  rab11 family-interacting protein 4 isoform X1

    Conserved Domains (3) summary
    pfam09457
    Location:573 → 613
    RBD-FIP; FIP domain
    pfam13499
    Location:21 → 78
    EF-hand_7; EF-hand domain pair
    cl03075
    Location:405 → 489
    GrpE; nucleotide exchange factor GrpE

  2. XM_008768017.3 → XP_008766239.1  rab11 family-interacting protein 4 isoform X2

    Conserved Domains (2) summary
    pfam09457
    Location:516 → 556
    RBD-FIP; FIP domain
    cl03075
    Location:348 → 432
    GrpE; nucleotide exchange factor GrpE

  3. XM_006246904.5 → XP_006246966.1  rab11 family-interacting protein 4 isoform X3

    Conserved Domains (2) summary
    pfam09457
    Location:494 → 534
    RBD-FIP; FIP domain
    cl03075
    Location:326 → 410
    GrpE; nucleotide exchange factor GrpE

  4. XM_063269073.1 → XP_063125143.1  rab11 family-interacting protein 4 isoform X4

Nucleotide Protein Strain
Heading Accession and Version

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