U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Atad5 ATPase family, AAA domain containing 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 303348, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Atad5provided by RGD
Official Full Name
ATPase family, AAA domain containing 5provided by RGD
Primary source
RGD:1561464
See related
EnsemblRapid:ENSRNOG00000021903 AllianceGenome:RGD:1561464
Gene type
protein coding
RefSeq status
MODEL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1561464
Summary
Predicted to enable DNA binding activity and DNA clamp unloader activity. Predicted to be involved in several processes, including negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; positive regulation of DNA replication; and positive regulation of cell cycle G2/M phase transition. Predicted to act upstream of or within several processes, including intracellular signal transduction; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage; and positive regulation of B cell activation. Predicted to be part of Elg1 RFC-like complex. Predicted to be active in nucleus. Orthologous to human ATAD5 (ATPase family AAA domain containing 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 103.6), Spleen (RPKM 72.4) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Atad5 in Genome Data Viewer
Location:
10q25
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (65568569..65616379)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (65070682..65118489)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (67427042..67475825)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene SUZ12 polycomb repressive complex 2 subunit Neighboring gene ribosomal protein L12, pseudogene 6 Neighboring gene cytokine receptor-like factor 3 Neighboring gene phosphoglycerate mutase 1, pseudogene 3 Neighboring gene transcription elongation factor, mitochondrial

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA clamp unloader activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA clamp unloader activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in DNA clamp unloading IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA damage response ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of isotype switching ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator ISO
Inferred from Sequence Orthology
more info
  
involved_in nuclear DNA replication ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of B cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA replication ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell cycle G2/M phase transition ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of isotype switching to IgG isotypes ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of mitotic cell cycle phase transition ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within signal transduction in response to DNA damage ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of Elg1 RFC-like complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
ATPase family AAA domain-containing protein 5

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    65568569..65616379
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_220750.11 → XP_220750.6  ATPase family AAA domain-containing protein 5 isoform X1

    See identical proteins and their annotated locations for XP_220750.6

    UniProtKB/TrEMBL
    A6HHA2, D4A058
    Related
    ENSRNOP00000028975.5, ENSRNOT00000035642.8
    Conserved Domains (1) summary
    cl21455
    Location:1121 → 1166
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  2. XM_039087647.2 → XP_038943575.1  ATPase family AAA domain-containing protein 5 isoform X2

    UniProtKB/TrEMBL
    A6HHA2
    Related
    ENSRNOP00000099936.1, ENSRNOT00000133075.1
    Conserved Domains (1) summary
    PRK04195
    Location:1045 → 1348
    PRK04195; replication factor C large subunit; Provisional

  3. XM_006246963.5 → XP_006247025.1  ATPase family AAA domain-containing protein 5 isoform X3

    See identical proteins and their annotated locations for XP_006247025.1

    UniProtKB/TrEMBL
    A6HHA2
    Related
    ENSRNOP00000108956.1, ENSRNOT00000136626.1
    Conserved Domains (1) summary
    cl21455
    Location:1058 → 1103
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RNA

  1. XR_010055697.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools