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Slfn5 schlafen family member 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 303377, updated on 2-Nov-2024

Summary

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Official Symbol
Slfn5provided by RGD
Official Full Name
schlafen family member 5provided by RGD
Primary source
RGD:1312025
See related
EnsemblRapid:ENSRNOG00000021719 AllianceGenome:RGD:1312025
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable ATP binding activity. Predicted to be located in nucleus. Orthologous to human SLFN5 (schlafen family member 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Spleen (RPKM 462.8), Lung (RPKM 412.7) and 9 other tissues See more
Orthologs
human all
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Genomic context

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See Slfn5 in Genome Data Viewer
Location:
10q26
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (68378440..68392515)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (67881068..67895013)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (70298094..70312062)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene fibronectin type III domain containing 8 Neighboring gene notchless homolog 1 Neighboring gene unc-45 myosin chaperone B Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like Neighboring gene large ribosomal subunit protein uL18-like Neighboring gene schlafen family member 9 Neighboring gene spindle and kinetochore-associated protein 2 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Subcellular localization of the Schlafen protein family. Neumann B, et al. Biochem Biophys Res Commun, 2008 May 23. PMID 18355440

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
schlafen family member 5
Names
schlafen 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001430188.1 → NP_001417117.1  schlafen family member 5 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A0A096MK60

  2. NM_001430189.1 → NP_001417118.1  schlafen family member 5 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    68378440..68392515
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063270130.1 → XP_063126200.1  schlafen family member 5

    Related
    ENSRNOP00000068390.3, ENSRNOT00000076445.4

  2. XM_220775.9 → XP_220775.3  schlafen family member 5

    See identical proteins and their annotated locations for XP_220775.3

    UniProtKB/TrEMBL
    A0A096MK60
    Related
    ENSRNOP00000037767.8, ENSRNOT00000035730.8
    Conserved Domains (4) summary
    PHA02782
    Location:36 → 327
    PHA02782; hypothetical protein; Provisional
    pfam04326
    Location:187 → 295
    AlbA_2; Putative DNA-binding domain
    cl21455
    Location:569 → 668
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    cl22977
    Location:832 → 880
    UvrD_C_2; UvrD-like helicase C-terminal domain
Nucleotide Protein Strain
Heading Accession and Version

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