U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Slfn2 schlafen family member 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 303380, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Slfn2provided by RGD
Official Full Name
schlafen family member 2provided by RGD
Primary source
RGD:1308645
See related
EnsemblRapid:ENSRNOG00000037113 AllianceGenome:RGD:1308645
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable tRNA binding activity. Predicted to be involved in T cell mediated immunity; T cell proliferation involved in immune response; and tRNA stabilization. Predicted to act upstream of or within negative regulation of cell population proliferation and response to bacterium. Predicted to be active in cytoplasm. Orthologous to human SLFN12L (schlafen family member 12 like). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Spleen (RPKM 713.5), Thymus (RPKM 499.7) and 7 other tissues See more
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Slfn2 in Genome Data Viewer
Location:
10q26
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (68450861..68457198)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (67953322..67959659)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (70370381..70376718)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like Neighboring gene large ribosomal subunit protein uL18-like Neighboring gene schlafen family member 9 Neighboring gene spindle and kinetochore-associated protein 2 pseudogene Neighboring gene schlafen family member 1 Neighboring gene schlafen family member 4 Neighboring gene glutathione S-transferase, alpha 4 like 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables tRNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in T cell mediated immunity ISO
Inferred from Sequence Orthology
more info
  
involved_in T cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in T cell proliferation involved in immune response ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within response to bacterium ISO
Inferred from Sequence Orthology
more info
  
involved_in tRNA stabilization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
schlafen family member 12-like
Names
schlafen 2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107031.1 → NP_001100501.1  schlafen family member 12-like

    See identical proteins and their annotated locations for NP_001100501.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473948
    UniProtKB/TrEMBL
    A0A096MJK8, A6HHF9
    Conserved Domains (2) summary
    pfam04326
    Location:231 → 340
    AlbA_2; Putative DNA-binding domain
    pfam17057
    Location:123 → 231
    B3R; Poxviridae B3 protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    68450861..68457198
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039086039.2 → XP_038941967.1  schlafen family member 12-like isoform X1

    UniProtKB/TrEMBL
    A0A096MJK8, D4A2D6
    Related
    ENSRNOP00000052810.3, ENSRNOT00000055957.5
    Conserved Domains (1) summary
    PHA02782
    Location:17 → 339
    PHA02782; hypothetical protein; Provisional
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.