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Usp32 ubiquitin specific peptidase 32 [ Rattus norvegicus (Norway rat) ]

Gene ID: 303394, updated on 10-Jul-2024

Summary

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Official Symbol
Usp32provided by RGD
Official Full Name
ubiquitin specific peptidase 32provided by RGD
Primary source
RGD:1306657
See related
EnsemblRapid:ENSRNOG00000027711 AllianceGenome:RGD:1306657
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable thiol-dependent deubiquitinase. Predicted to be involved in protein deubiquitination and ubiquitin-dependent protein catabolic process. Predicted to be located in cytosol. Predicted to be active in Golgi apparatus. Orthologous to human USP32 (ubiquitin specific peptidase 32). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 221.0), Adrenal (RPKM 211.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Usp32 in Genome Data Viewer
Location:
10q26
Exon count:
39
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (70353310..70538008, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (69855895..70029075, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (72300173..72474574, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L37A, pseudogene 3 Neighboring gene carbonic anhydrase 4 Neighboring gene DAB adaptor protein 1, pseudogene 1 Neighboring gene tetra-peptide repeat homeobox-like protein Neighboring gene large ribosomal subunit protein eL21-like Neighboring gene CHD1 helical C-terminal domain containing 1 Neighboring gene amyloid beta precursor protein binding protein 2 Neighboring gene protein phosphatase, Mg2+/Mn2+ dependent, 1D

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. USP32 is an active, membrane-bound ubiquitin protease overexpressed in breast cancers. Akhavantabasi S, et al. Mamm Genome, 2010 Aug. PMID 20549504
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables cysteine-type deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in positive regulation of TORC1 signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ubiquitin carboxyl-terminal hydrolase 32
Names
ubiquitin specific protease 32
NP_001388596.1
XP_017452797.1
XP_038941969.1
XP_038941970.1
XP_063125160.1
XP_063125161.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001401667.1 → NP_001388596.1  ubiquitin carboxyl-terminal hydrolase 32

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A0A8I6A5X2
    Related
    ENSRNOP00000111074.1, ENSRNOT00000170376.1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    70353310..70538008 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017597308.3 → XP_017452797.1  ubiquitin carboxyl-terminal hydrolase 32 isoform X2

    UniProtKB/TrEMBL
    A0A8I6A5X2
    Related
    ENSRNOP00000074862.3, ENSRNOT00000081649.3

  2. XM_039086041.2 → XP_038941969.1  ubiquitin carboxyl-terminal hydrolase 32 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A5X2
    Conserved Domains (3) summary
    COG5126
    Location:254 → 404
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    COG5560
    Location:583 → 1395
    UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
    pfam00443
    Location:1314 → 1643
    UCH; Ubiquitin carboxyl-terminal hydrolase

  3. XM_063269091.1 → XP_063125161.1  ubiquitin carboxyl-terminal hydrolase 32 isoform X5

    UniProtKB/TrEMBL
    A0A8I6A5X2
    Related
    ENSRNOP00000031281.4, ENSRNOT00000036814.7

  4. XM_039086042.2 → XP_038941970.1  ubiquitin carboxyl-terminal hydrolase 32 isoform X3

    UniProtKB/TrEMBL
    A0A8I6A5X2
    Related
    ENSRNOP00000088848.1, ENSRNOT00000111648.2
    Conserved Domains (3) summary
    COG5126
    Location:189 → 339
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    COG5560
    Location:518 → 1330
    UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
    pfam00443
    Location:1249 → 1578
    UCH; Ubiquitin carboxyl-terminal hydrolase

  5. XM_063269090.1 → XP_063125160.1  ubiquitin carboxyl-terminal hydrolase 32 isoform X4

    UniProtKB/TrEMBL
    A0A8I6A5X2

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001107032.1: Suppressed sequence

    Description
    NM_001107032.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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