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Mpo myeloperoxidase [ Rattus norvegicus (Norway rat) ]

Gene ID: 303413, updated on 2-Nov-2024

Summary

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Official Symbol
Mpoprovided by RGD
Official Full Name
myeloperoxidaseprovided by RGD
Primary source
RGD:1592081
See related
EnsemblRapid:ENSRNOG00000008310 AllianceGenome:RGD:1592081
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables peroxidase activity. Involved in several processes, including response to food; response to gold nanoparticle; and response to lipopolysaccharide. Located in extracellular space. Used to study acute kidney failure. Biomarker of chronic obstructive pulmonary disease; cystitis; and renovascular hypertension. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease 1; cystic fibrosis; kidney failure (multiple); liver disease (multiple); and lung disease (multiple). Orthologous to human MPO (myeloperoxidase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Spleen (RPKM 105.3), Thymus (RPKM 100.8) and 4 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mpo in Genome Data Viewer
Location:
10q26
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (73092124..73102057)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (72594883..72608862)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (75087892..75098260)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480847 Neighboring gene SPT4 homolog, DSIF elongation factor subunit Neighboring gene TSPO associated protein 1 Neighboring gene microRNA 142 Neighboring gene lactoperoxidase Neighboring gene MKS transition zone complex subunit 1 Neighboring gene eosinophil peroxidase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Endogenous myeloperoxidase promotes neutrophil-mediated renal injury, but attenuates T cell immunity inducing crescentic glomerulonephritis. Odobasic D, et al. J Am Soc Nephrol, 2007 Mar. PMID 17267745
  2. Diazoxide attenuates indomethacin-induced small intestinal damage in the rat. Menozzi A, et al. Eur J Pharmacol, 2011 Jan 10. PMID 20950601
  3. Effect of sodium bicarbonate in an experimental model of radiocontrast nephropathy. Barlak A, et al. Ren Fail, 2010. PMID 20722568
  4. Prognostic value of plasma myeloperoxidase in ESRD patients. Wang AY, et al. Am J Kidney Dis, 2010 Nov. PMID 20638167
  5. Halofuginone has a beneficial effect on gentamicin-induced acute nephrotoxicity in rats. Karakoyun B, et al. Drug Chem Toxicol, 2009. PMID 19793022

See all (86) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Circ-Plod2 destabilizes Mpo mRNA by binding to IGF2BP2 to promote osteogenic differentiation of bone marrow mesenchymal stem cells.
    Title: Circ-Plod2 destabilizes Mpo mRNA by binding to IGF2BP2 to promote osteogenic differentiation of bone marrow mesenchymal stem cells.
  2. Myeloperoxidase instigates proinflammatory responses in a cecal ligation and puncture rat model of sepsis.
    Title: Myeloperoxidase instigates proinflammatory responses in a cecal ligation and puncture rat model of sepsis.
  3. These results indicate significant increases of MPO-immunoreactive cells in brain regions affected by neurodegeneration in Parkinson's disease and Alzheimer's Disease.
    Title: Myeloperoxidase-immunoreactive cells are significantly increased in brain areas affected by neurodegeneration in Parkinson's and Alzheimer's disease.
  4. Maternal and fetal detrimental changes along with increases in circulating sFlt-1 and VEGF in hypertensive pregnancy may be associated with increases in cardiac and circulating MPO activities, confirming the causative role of inflammatory response in preeclampsia.
    Title: Cardiac myeloperoxidase activity is elevated in hypertensive pregnant rats.
  5. Consistent with these in vitro data, in diabetic rat aortas, both MPO expresion and NADPH oxidase activity were increased while the endothelial function was simultaneously impaired. The results suggested that vascular-bound MPO could amplify high glucose-induced vascular injury in diabetes. MPO-NADPH oxidase-HOCl may represent an important pathogenic pathway in diabetic vascular diseases.
    Title: Myeloperoxidase amplified high glucose-induced endothelial dysfunction in vasculature: Role of NADPH oxidase and hypochlorous acid.
  6. While myocardial TLR4, MPO and ADMA levels increased in the MIR group, these parameters were found to be decreased significantly in the group treated with apocynin.
    Title: Effects of apocynin, an NADPH oxidase inhibitor, on levels of ADMA, MPO, iNOS and TLR4 induced by myocardial ischemia reperfusion.
  7. Upregulation of MPO concomitant with endothelial senescence and dysfunction in hyperlipidemic rats.
    Title: Myeloperoxidase-derived hypochlorous acid promotes ox-LDL-induced senescence of endothelial cells through a mechanism involving β-catenin signaling in hyperlipidemia.
  8. the role of leukocyte activation, leukocyte-derived MPO and MPO-generated oxidants on BBB function
    Title: Myeloperoxidase-derived oxidants induce blood-brain barrier dysfunction in vitro and in vivo.
  9. MPO has dual functionality under rotenone-exposed conditions, playing a critical regulatory role in modulating pathological and protective events in the brain
    Title: Dual functionality of myeloperoxidase in rotenone-exposed brain-resident immune cells.
  10. results demonstrate that, increased expression of MPO in damaged rat and human liver is due to recruited elastase positive neutrophil granulocytes
    Title: Myeloperoxidase and elastase are only expressed by neutrophils in normal and in inflamed liver.
Submit: New GeneRIF Correction See all GeneRIFs (20)

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables heparin binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables peroxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peroxidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables peroxidase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
NOT acts_upstream_of_or_within defense response to Gram-positive bacterium ISO
Inferred from Sequence Orthology
more info
  
involved_in defense response to bacterium IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within defense response to fungus ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within hydrogen peroxide catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in hydrogen peroxide catabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within hypochlorous acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in low-density lipoprotein particle remodeling ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within removal of superoxide radicals ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within respiratory burst involved in defense response ISO
Inferred from Sequence Orthology
more info
  
involved_in response to food IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to gold nanoparticle IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to lipopolysaccharide IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to mechanical stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to oxidative stress IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within response to yeast ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in azurophil granule ISO
Inferred from Sequence Orthology
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in secretory granule ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
myeloperoxidase
NP_001388741.1
XP_006247157.1
XP_006247158.1
XP_063125167.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001401812.1 → NP_001388741.1  myeloperoxidase precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    73092124..73102057
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006247096.5 → XP_006247158.1  myeloperoxidase isoform X1

    See identical proteins and their annotated locations for XP_006247158.1

    UniProtKB/TrEMBL
    A0A0G2K1A2
    Related
    ENSRNOP00000071759.2, ENSRNOT00000081951.3
    Conserved Domains (1) summary
    cd09824
    Location:289 → 702
    myeloperoxidase_like; Myeloperoxidases, eosinophil peroxidases, and lactoperoxidases

  2. XM_006247095.4 → XP_006247157.1  myeloperoxidase isoform X1

    See identical proteins and their annotated locations for XP_006247157.1

    UniProtKB/TrEMBL
    A0A0G2K1A2
    Conserved Domains (1) summary
    cd09824
    Location:289 → 702
    myeloperoxidase_like; Myeloperoxidases, eosinophil peroxidases, and lactoperoxidases

  3. XM_063269097.1 → XP_063125167.1  myeloperoxidase isoform X1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001107036.1: Suppressed sequence

    Description
    NM_001107036.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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