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Arhgap23 Rho GTPase activating protein 23 [ Rattus norvegicus (Norway rat) ]

Gene ID: 303501, updated on 2-Nov-2024

Summary

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Official Symbol
Arhgap23provided by RGD
Official Full Name
Rho GTPase activating protein 23provided by RGD
Primary source
RGD:1309742
See related
EnsemblRapid:ENSRNOG00000022771 AllianceGenome:RGD:1309742
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Arhgap23l
Summary
Predicted to enable GTPase activator activity. Predicted to be involved in signal transduction. Orthologous to human ARHGAP23 (Rho GTPase activating protein 23). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Spleen (RPKM 48.7), Brain (RPKM 39.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Arhgap23 in Genome Data Viewer
Location:
10q31
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (82891021..82993230)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (82437578..82496846)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (85387219..85445805)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene dual specificity protein phosphatase 26 pseudogene Neighboring gene suppressor of cytokine signaling 7 Neighboring gene uncharacterized LOC134480864 Neighboring gene SRC kinase signaling inhibitor 1 Neighboring gene uncharacterized LOC102548331 Neighboring gene uncharacterized LOC134480715

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Sequential Elution Interactome Analysis of the Mind Bomb 1 Ubiquitin Ligase Reveals a Novel Role in Dendritic Spine Outgrowth. Mertz J, et al. Mol Cell Proteomics, 2015 Jul. PMID 25931508, Free PMC Article
  2. Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). Gonzalez-Begne M, et al. J Proteome Res, 2009 Mar. PMID 19199708, Free PMC Article

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
rho GTPase-activating protein 23
Names
Rho GTPase activating protein 23 like
pulmonary surfactant-associated protein D-like
translation initiation factor IF-2-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001428749.1 → NP_001415678.1  rho GTPase-activating protein 23

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    F1M2D4

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    82891021..82993230
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063270144.1 → XP_063126214.1  rho GTPase-activating protein 23 isoform X6

  2. XM_063270145.1 → XP_063126215.1  rho GTPase-activating protein 23 isoform X7

    UniProtKB/TrEMBL
    A0A8I6AMV0
    Related
    ENSRNOP00000095322.1, ENSRNOT00000100892.2

  3. XM_063270143.1 → XP_063126213.1  rho GTPase-activating protein 23 isoform X5

  4. XM_063270146.1 → XP_063126216.1  rho GTPase-activating protein 23 isoform X10

    Related
    ENSRNOP00000032436.7, ENSRNOT00000034305.8

  5. XM_017597699.3 → XP_017453188.1  rho GTPase-activating protein 23 isoform X3

    Conserved Domains (4) summary
    cd00992
    Location:4 → 57
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04395
    Location:754 → 949
    RhoGAP_ARHGAP21; RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the ...
    cd01253
    Location:542 → 662
    PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
    pfam00169
    Location:541 → 660
    PH; PH domain

  6. XM_006247437.3 → XP_006247499.1  rho GTPase-activating protein 23 isoform X1

    Conserved Domains (4) summary
    cd00992
    Location:4 → 57
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04395
    Location:806 → 1001
    RhoGAP_ARHGAP21; RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the ...
    cd01253
    Location:594 → 714
    PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
    pfam00169
    Location:593 → 712
    PH; PH domain

  7. XM_039087723.2 → XP_038943651.1  rho GTPase-activating protein 23 isoform X2

    UniProtKB/TrEMBL
    A0A8I6AA04
    Conserved Domains (4) summary
    PHA03247
    Location:89 → 481
    PHA03247; large tegument protein UL36; Provisional
    cd00992
    Location:4 → 57
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04395
    Location:806 → 1001
    RhoGAP_ARHGAP21; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction ...
    cd01253
    Location:594 → 714
    PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain

  8. XM_008768199.4 → XP_008766421.1  rho GTPase-activating protein 23 isoform X4

    Conserved Domains (3) summary
    cd00992
    Location:4 → 57
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04395
    Location:723 → 918
    RhoGAP_ARHGAP21; RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the ...
    cl17171
    Location:498 → 631
    PH-like; Pleckstrin homology-like domain

  9. XM_039087721.2 → XP_038943649.1  rho GTPase-activating protein 23 isoform X8

    Conserved Domains (4) summary
    PHA03247
    Location:89 → 481
    PHA03247; large tegument protein UL36; Provisional
    cd00992
    Location:4 → 57
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04395
    Location:806 → 1001
    RhoGAP_ARHGAP21; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction ...
    cd01253
    Location:594 → 714
    PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain

  10. XM_039087722.2 → XP_038943650.1  rho GTPase-activating protein 23 isoform X8

    Conserved Domains (4) summary
    PHA03247
    Location:89 → 481
    PHA03247; large tegument protein UL36; Provisional
    cd00992
    Location:4 → 57
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04395
    Location:806 → 1001
    RhoGAP_ARHGAP21; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction ...
    cd01253
    Location:594 → 714
    PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain

  11. XM_017597700.3 → XP_017453189.1  rho GTPase-activating protein 23 isoform X9

    Related
    ENSRNOP00000089331.2, ENSRNOT00000098656.2
    Conserved Domains (3) summary
    cd04395
    Location:694 → 889
    RhoGAP_ARHGAP21; RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the ...
    cd01253
    Location:482 → 602
    PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
    pfam00169
    Location:481 → 600
    PH; PH domain
Nucleotide Protein Strain
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