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Mllt6 MLLT6, PHD finger containing [ Rattus norvegicus (Norway rat) ]

Gene ID: 303504, updated on 2-Nov-2024

Summary

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Official Symbol
Mllt6provided by RGD
Official Full Name
MLLT6, PHD finger containingprovided by RGD
Primary source
RGD:1306689
See related
EnsemblRapid:ENSRNOG00000053285 AllianceGenome:RGD:1306689
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable histone binding activity and nucleosome binding activity. Predicted to act upstream of or within several processes, including renal potassium excretion; renal sodium excretion; and renal water absorption. Orthologous to human MLLT6 (MLLT6, PHD finger containing). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 98.8), Kidney (RPKM 96.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mllt6 in Genome Data Viewer
Location:
10q31
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (83152317..83175264)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (82657258..82678899)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (85607988..85628171)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102548331 Neighboring gene uncharacterized LOC134480715 Neighboring gene elongin BC and polycomb repressive complex 2 associated protein Neighboring gene uncharacterized LOC120095289 Neighboring gene CDGSH iron sulfur domain 3 Neighboring gene polycomb group ring finger 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Af17 deficiency increases sodium excretion and decreases blood pressure. Chen L, et al. J Am Soc Nephrol, 2011 Jun. PMID 21546577, Free PMC Article
  2. The PZP Domain of AF10 Senses Unmodified H3K27 to Regulate DOT1L-Mediated Methylation of H3K79. Chen S, et al. Mol Cell, 2015 Oct 15. PMID 26439302, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables histone binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleosome binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within chromatin organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of urine volume ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of sodium ion transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within renal potassium excretion ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within renal sodium excretion ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within renal system process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within renal water absorption ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein AF-17
Names
MLLT6, PHD finger domain containing
myeloid/lymphoid or mixed lineage-leukemia translocation to 6 homolog
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6
myeloid/lymphoid or mixed-lineage leukemia; translocated to, 6
translocated to, 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427040.2 → NP_001413969.1  protein AF-17

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    83152317..83175264
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039087724.2 → XP_038943652.1  protein AF-17 isoform X1

    Conserved Domains (3) summary
    cd15574
    Location:7 → 54
    PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
    cd15709
    Location:61 → 185
    ePHD_AF17; Extended PHD finger found in protein AF-17 and similar proteins
    cd20901
    Location:714 → 768
    CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins

  2. XM_063269120.1 → XP_063125190.1  protein AF-17 isoform X2

  3. XM_039087728.2 → XP_038943656.1  protein AF-17 isoform X5

    UniProtKB/TrEMBL
    A6HIL2
    Conserved Domains (2) summary
    cd15574
    Location:7 → 54
    PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
    cd15709
    Location:61 → 185
    ePHD_AF17; Extended PHD finger found in protein AF-17 and similar proteins

  4. XM_063269119.1 → XP_063125189.1  protein AF-17 isoform X1

  5. XM_039087726.2 → XP_038943654.1  protein AF-17 isoform X4

    Conserved Domains (3) summary
    cd15574
    Location:7 → 54
    PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
    cd15709
    Location:61 → 185
    ePHD_AF17; Extended PHD finger found in protein AF-17 and similar proteins
    cd20901
    Location:686 → 740
    CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins

  6. XM_039087725.2 → XP_038943653.1  protein AF-17 isoform X3

    UniProtKB/TrEMBL
    A0A0G2K809
    Related
    ENSRNOP00000074424.2, ENSRNOT00000092122.3
    Conserved Domains (3) summary
    cd15574
    Location:7 → 54
    PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
    cd15709
    Location:61 → 185
    ePHD_AF17; Extended PHD finger found in protein AF-17 and similar proteins
    cd20901
    Location:714 → 768
    CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins
Nucleotide Protein Strain
Heading Accession and Version

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