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Ghdc GH3 domain containing [ Rattus norvegicus (Norway rat) ]

Gene ID: 303542, updated on 2-Nov-2024

Summary

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Official Symbol
Ghdcprovided by RGD
Official Full Name
GH3 domain containingprovided by RGD
Primary source
RGD:1308881
See related
EnsemblRapid:ENSRNOG00000018906 AllianceGenome:RGD:1308881
Gene type
protein coding
RefSeq status
INFERRED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1308881
Summary
Predicted to enable acid-amino acid ligase activity. Predicted to be located in endoplasmic reticulum. Predicted to be active in cytoplasm. Orthologous to human GHDC (GH3 domain containing). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 44.4), Adrenal (RPKM 38.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ghdc in Genome Data Viewer
Location:
10q31
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (86193920..86198141, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (85693612..85697833, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (88672834..88677055, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene potassium voltage-gated channel subfamily H member 4 Neighboring gene uncharacterized LOC108352136 Neighboring gene hypocretin neuropeptide precursor Neighboring gene signal transducer and activator of transcription 5B Neighboring gene signal transducer and activator of transcription 5A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The Stat3/5 locus encodes novel endoplasmic reticulum and helicase-like proteins that are preferentially expressed in normal and neoplastic mammary tissue. Cui Y, et al. Genomics, 2001 Dec. PMID 11735219
  2. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables acid-amino acid ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
GH3 domain-containing protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191651.1 → NP_001178580.1  GH3 domain-containing protein

    Status: INFERRED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    D3ZX06
    Related
    ENSRNOP00000025590.4, ENSRNOT00000025590.8
    Conserved Domains (2) summary
    cl21606
    Location:248 → 526
    PLN02247; indole-3-acetic acid-amido synthetase
    pfam03321
    Location:54 → 497
    GH3; GH3 auxin-responsive promoter

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    86193920..86198141 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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