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Tanc2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 303599, updated on 10-Oct-2024

Summary

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Official Symbol
Tanc2provided by RGD
Official Full Name
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2provided by RGD
Primary source
RGD:1309285
See related
EnsemblRapid:ENSRNOG00000052840 AllianceGenome:RGD:1309285
Gene type
protein coding
RefSeq status
INFERRED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1309285
Summary
Involved in dense core granule cytoskeletal transport; regulation of dendritic spine development; and regulation of dendritic spine morphogenesis. Located in dendritic spine. Is active in glutamatergic synapse and postsynaptic density, intracellular component. Orthologous to human TANC2 (tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 130.9), Kidney (RPKM 121.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tanc2 in Genome Data Viewer
Location:
10q32.1
Exon count:
32
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (91052860..91373291)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (90553124..90873477)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (93811350..94132418)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480889 Neighboring gene transfer RNA valine (anticodon AAC) 25 Neighboring gene U4 spliceosomal RNA Neighboring gene uncharacterized LOC120095191 Neighboring gene U6 spliceosomal RNA Neighboring gene snurportin 1, pseudogene 1 Neighboring gene uncharacterized LOC120095193 Neighboring gene cytochrome b-561 Neighboring gene angiotensin I converting enzyme

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Regulation of dendritic spines, spatial memory, and embryonic development by the TANC family of PSD-95-interacting proteins. Han S, et al. J Neurosci, 2010 Nov 10. PMID 21068316, Free PMC Article
  2. Regulation of KIF1A-Driven Dense Core Vesicle Transport: Ca(2+)/CaM Controls DCV Binding and Liprin-α/TANC2 Recruits DCVs to Postsynaptic Sites. Stucchi R, et al. Cell Rep, 2018 Jul 17. PMID 30021165, Free PMC Article
  3. Seizures are regulated by ubiquitin-specific peptidase 9 X-linked (USP9X), a de-ubiquitinase. Paemka L, et al. PLoS Genet, 2015 Mar. PMID 25763846, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. liprin-alpha and TANC2 are not part of the KIF1A-cargo complex but capture dense core vesicles at dendritic spines.
    Title: Regulation of KIF1A-Driven Dense Core Vesicle Transport: Ca(2+)/CaM Controls DCV Binding and Liprin-α/TANC2 Recruits DCVs to Postsynaptic Sites.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables structural constituent of postsynaptic density EXP
Inferred from Experiment
more info
 PubMed 
enables structural constituent of postsynaptic density IDA
Inferred from Direct Assay
more info
 PubMed 
enables structural constituent of postsynaptic density IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in dense core granule cytoskeletal transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in in utero embryonic development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within in utero embryonic development ISO
Inferred from Sequence Orthology
more info
  
involved_in maintenance of postsynaptic density structure IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of dendritic spine development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of dendritic spine morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in axon IEA
Inferred from Electronic Annotation
more info
  
located_in dendritic spine IDA
Inferred from Direct Assay
more info
 PubMed 
located_in dendritic spine ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse EXP
Inferred from Experiment
more info
 PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in postsynaptic density IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynaptic density IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in postsynaptic density, intracellular component IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynaptic density, intracellular component IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein TANC2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191653.1 → NP_001178582.1  protein TANC2

    Status: INFERRED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/Swiss-Prot
    F1LTE0
    UniProtKB/TrEMBL
    A6HJY7
    Related
    ENSRNOP00000075014.3, ENSRNOT00000081937.3
    Conserved Domains (7) summary
    PHA03095
    Location:856 → 1150
    PHA03095; ankyrin-like protein; Provisional
    PHA03378
    Location:1493 → 1637
    PHA03378; EBNA-3B; Provisional
    COG0457
    Location:1240 → 1357
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    COG0666
    Location:1096 → 1222
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00006
    Location:1247 → 1272
    TPR; TPR repeat [structural motif]
    sd00045
    Location:1100 → 1130
    ANK; ANK repeat [structural motif]
    pfam13191
    Location:341 → 427
    AAA_16; AAA ATPase domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    91052860..91373291
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039086155.2 → XP_038942083.1  protein TANC2 isoform X7

    UniProtKB/TrEMBL
    A0A0G2K9J0
    Conserved Domains (6) summary
    PHA03095
    Location:859 → 1153
    PHA03095; ankyrin-like protein; Provisional
    PHA03247
    Location:1442 → 1637
    PHA03247; large tegument protein UL36; Provisional
    COG0457
    Location:1253 → 1371
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    COG0666
    Location:1099 → 1225
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00006
    Location:1260 → 1285
    TPR; TPR repeat [structural motif]
    sd00045
    Location:1103 → 1133
    ANK; ANK repeat [structural motif]

  2. XM_039086153.2 → XP_038942081.1  protein TANC2 isoform X7

    UniProtKB/TrEMBL
    A0A0G2K9J0
    Conserved Domains (6) summary
    PHA03095
    Location:859 → 1153
    PHA03095; ankyrin-like protein; Provisional
    PHA03247
    Location:1442 → 1637
    PHA03247; large tegument protein UL36; Provisional
    COG0457
    Location:1253 → 1371
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    COG0666
    Location:1099 → 1225
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00006
    Location:1260 → 1285
    TPR; TPR repeat [structural motif]
    sd00045
    Location:1103 → 1133
    ANK; ANK repeat [structural motif]

  3. XM_039086147.2 → XP_038942075.1  protein TANC2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K9J0
    Conserved Domains (6) summary
    PHA03095
    Location:930 → 1224
    PHA03095; ankyrin-like protein; Provisional
    PHA03247
    Location:1513 → 1708
    PHA03247; large tegument protein UL36; Provisional
    COG0457
    Location:1324 → 1442
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    COG0666
    Location:1170 → 1296
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00006
    Location:1331 → 1356
    TPR; TPR repeat [structural motif]
    sd00045
    Location:1174 → 1204
    ANK; ANK repeat [structural motif]

  4. XM_008768351.4 → XP_008766573.1  protein TANC2 isoform X2

    See identical proteins and their annotated locations for XP_008766573.1

    UniProtKB/TrEMBL
    A0A0G2K9J0, A0A8L2R2A4
    Related
    ENSRNOP00000069281.2, ENSRNOT00000077280.3
    Conserved Domains (10) summary
    cd00204
    Location:1168 → 1293
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00006
    Location:1331 → 1356
    TPR; TPR repeat [structural motif]
    pfam03153
    Location:1490 → 1715
    TFIIA; Transcription factor IIA, alpha/beta subunit
    pfam12796
    Location:1178 → 1270
    Ank_2; Ankyrin repeats (3 copies)
    pfam13191
    Location:415 → 501
    AAA_16; AAA ATPase domain
    pfam13414
    Location:1377 → 1440
    TPR_11; TPR repeat
    pfam13428
    Location:1410 → 1452
    TPR_14; Tetratricopeptide repeat
    pfam13637
    Location:962 → 1011
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:1174 → 1204
    ANK; ANK repeat [structural motif]
    cl14876
    Location:469 → 613
    Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42

  5. XM_039086149.2 → XP_038942077.1  protein TANC2 isoform X3

    UniProtKB/TrEMBL
    A0A0G2K9J0
    Conserved Domains (6) summary
    PHA03095
    Location:930 → 1224
    PHA03095; ankyrin-like protein; Provisional
    PHA03247
    Location:1503 → 1698
    PHA03247; large tegument protein UL36; Provisional
    COG0457
    Location:1314 → 1432
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    COG0666
    Location:1170 → 1296
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00006
    Location:1321 → 1346
    TPR; TPR repeat [structural motif]
    sd00045
    Location:1174 → 1204
    ANK; ANK repeat [structural motif]

  6. XM_008768353.4 → XP_008766575.1  protein TANC2 isoform X4

    UniProtKB/TrEMBL
    A0A0G2K9J0
    Related
    ENSRNOP00000111586.1, ENSRNOT00000146875.1
    Conserved Domains (10) summary
    cd00204
    Location:1168 → 1293
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00006
    Location:1321 → 1346
    TPR; TPR repeat [structural motif]
    pfam03153
    Location:1480 → 1705
    TFIIA; Transcription factor IIA, alpha/beta subunit
    pfam12796
    Location:1178 → 1270
    Ank_2; Ankyrin repeats (3 copies)
    pfam13191
    Location:415 → 501
    AAA_16; AAA ATPase domain
    pfam13414
    Location:1367 → 1430
    TPR_11; TPR repeat
    pfam13428
    Location:1400 → 1442
    TPR_14; Tetratricopeptide repeat
    pfam13637
    Location:962 → 1011
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:1174 → 1204
    ANK; ANK repeat [structural motif]
    cl14876
    Location:469 → 613
    Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42

  7. XM_039086150.2 → XP_038942078.1  protein TANC2 isoform X5

    UniProtKB/TrEMBL
    A0A0G2K9J0
    Conserved Domains (7) summary
    PHA03095
    Location:893 → 1187
    PHA03095; ankyrin-like protein; Provisional
    PHA03247
    Location:1476 → 1671
    PHA03247; large tegument protein UL36; Provisional
    COG0457
    Location:1287 → 1405
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    COG0666
    Location:1133 → 1259
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00006
    Location:1294 → 1319
    TPR; TPR repeat [structural motif]
    sd00045
    Location:1137 → 1167
    ANK; ANK repeat [structural motif]
    pfam13191
    Location:378 → 464
    AAA_16; AAA ATPase domain

  8. XM_039086151.2 → XP_038942079.1  protein TANC2 isoform X6

    UniProtKB/TrEMBL
    A6HJY7
    Conserved Domains (7) summary
    PHA03095
    Location:893 → 1187
    PHA03095; ankyrin-like protein; Provisional
    PHA03247
    Location:1476 → 1671
    PHA03247; large tegument protein UL36; Provisional
    COG0457
    Location:1287 → 1405
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    COG0666
    Location:1133 → 1259
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00006
    Location:1294 → 1319
    TPR; TPR repeat [structural motif]
    sd00045
    Location:1137 → 1167
    ANK; ANK repeat [structural motif]
    pfam13191
    Location:378 → 464
    AAA_16; AAA ATPase domain

  9. XM_039086157.2 → XP_038942085.1  protein TANC2 isoform X8

    UniProtKB/TrEMBL
    A6HJY7
    Conserved Domains (7) summary
    PHA03095
    Location:856 → 1150
    PHA03095; ankyrin-like protein; Provisional
    PHA03247
    Location:1439 → 1634
    PHA03247; large tegument protein UL36; Provisional
    COG0457
    Location:1250 → 1368
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    COG0666
    Location:1096 → 1222
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00006
    Location:1257 → 1282
    TPR; TPR repeat [structural motif]
    sd00045
    Location:1100 → 1130
    ANK; ANK repeat [structural motif]
    pfam13191
    Location:341 → 427
    AAA_16; AAA ATPase domain

  10. XM_063269198.1 → XP_063125268.1  protein TANC2 isoform X9

  11. XM_039086154.2 → XP_038942082.1  protein TANC2 isoform X7

    UniProtKB/TrEMBL
    A0A0G2K9J0
    Conserved Domains (6) summary
    PHA03095
    Location:859 → 1153
    PHA03095; ankyrin-like protein; Provisional
    PHA03247
    Location:1442 → 1637
    PHA03247; large tegument protein UL36; Provisional
    COG0457
    Location:1253 → 1371
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    COG0666
    Location:1099 → 1225
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00006
    Location:1260 → 1285
    TPR; TPR repeat [structural motif]
    sd00045
    Location:1103 → 1133
    ANK; ANK repeat [structural motif]

  12. XM_039086152.1 → XP_038942080.1  protein TANC2 isoform X7

    UniProtKB/TrEMBL
    A0A0G2K9J0
    Conserved Domains (6) summary
    PHA03095
    Location:859 → 1153
    PHA03095; ankyrin-like protein; Provisional
    PHA03247
    Location:1442 → 1637
    PHA03247; large tegument protein UL36; Provisional
    COG0457
    Location:1253 → 1371
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    COG0666
    Location:1099 → 1225
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00006
    Location:1260 → 1285
    TPR; TPR repeat [structural motif]
    sd00045
    Location:1103 → 1133
    ANK; ANK repeat [structural motif]

  13. XM_039086159.2 → XP_038942087.1  protein TANC2 isoform X10

    UniProtKB/TrEMBL
    A6HJY7
    Conserved Domains (7) summary
    PHA03095
    Location:766 → 1060
    PHA03095; ankyrin-like protein; Provisional
    PHA03247
    Location:1349 → 1544
    PHA03247; large tegument protein UL36; Provisional
    COG0457
    Location:1160 → 1278
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    COG0666
    Location:1006 → 1132
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00006
    Location:1167 → 1192
    TPR; TPR repeat [structural motif]
    sd00045
    Location:1010 → 1040
    ANK; ANK repeat [structural motif]
    pfam13191
    Location:251 → 337
    AAA_16; AAA ATPase domain

  14. XM_039086156.2 → XP_038942084.1  protein TANC2 isoform X7

    UniProtKB/TrEMBL
    A0A0G2K9J0
    Conserved Domains (6) summary
    PHA03095
    Location:859 → 1153
    PHA03095; ankyrin-like protein; Provisional
    PHA03247
    Location:1442 → 1637
    PHA03247; large tegument protein UL36; Provisional
    COG0457
    Location:1253 → 1371
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    COG0666
    Location:1099 → 1225
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00006
    Location:1260 → 1285
    TPR; TPR repeat [structural motif]
    sd00045
    Location:1103 → 1133
    ANK; ANK repeat [structural motif]

  15. XM_039086158.2 → XP_038942086.1  protein TANC2 isoform X10

    UniProtKB/TrEMBL
    A6HJY7
    Conserved Domains (7) summary
    PHA03095
    Location:766 → 1060
    PHA03095; ankyrin-like protein; Provisional
    PHA03247
    Location:1349 → 1544
    PHA03247; large tegument protein UL36; Provisional
    COG0457
    Location:1160 → 1278
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    COG0666
    Location:1006 → 1132
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00006
    Location:1167 → 1192
    TPR; TPR repeat [structural motif]
    sd00045
    Location:1010 → 1040
    ANK; ANK repeat [structural motif]
    pfam13191
    Location:251 → 337
    AAA_16; AAA ATPase domain

  16. XM_039086160.2 → XP_038942088.1  protein TANC2 isoform X10

    UniProtKB/TrEMBL
    A6HJY7
    Conserved Domains (7) summary
    PHA03095
    Location:766 → 1060
    PHA03095; ankyrin-like protein; Provisional
    PHA03247
    Location:1349 → 1544
    PHA03247; large tegument protein UL36; Provisional
    COG0457
    Location:1160 → 1278
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    COG0666
    Location:1006 → 1132
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00006
    Location:1167 → 1192
    TPR; TPR repeat [structural motif]
    sd00045
    Location:1010 → 1040
    ANK; ANK repeat [structural motif]
    pfam13191
    Location:251 → 337
    AAA_16; AAA ATPase domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
F1LTE0.2 GenPept UniProtKB/Swiss-Prot:F1LTE0

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